NFL - Odds & Predictions

Steelers vs Colts Prediction, Odds & Best Bets for Monday Night Football (Mike Tomlin Guides Pittsburgh to Victory)

Larry Rupp
Pittsburgh Steelers vs Indianapolis Colts prediction, odds and best bets for NFL Week 12 game.
Pittsburgh Steelers vs Indianapolis Colts prediction, odds and best bets for NFL Week 12 game. / AP Photos/Don Wright
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Steelers vs Colts Week 12 Game Info

2022 NFL Regular Season — Week 12
Pittsburgh Steelers (3-7, 1-4 Away) vs. Indianapolis Colts (4-6-1, 2-3 Home)
Date: Monday, Nov. 28, 2022
Time: 8:15 p.m. ET
Venue: Lucas Oil Stadium — Indianapolis, IN
Coverage: ESPN

Two teams vying to remain in the AFC playoff race meet head-to-head in Week 12 as the Pittsburgh Steelers visit the Indianapolis Colts. The Steelers fell short in a 37-30 loss to the Cincinnati Bengals on Sunday. Running back Najee Harris logged 116 total yards and 2 touchdowns on 24 touches.

Meanwhile, the Colts gave up a late touchdown to the Philadelphia Eagles in what ended up being a 17-16 Week 11 loss. Running back Jonathan Taylor paved the way on offense with 94 total yards and 1 touchdown on 25 touches. Indianapolis averaged a dismal 3.8 yards per carry as a team, though.

Steelers vs Colts Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PIT: (+122) | IND: (-144)
Spread: PIT: +2.5 (-105) | IND: -2.5 (-115)
Total: 39.5 — Over: (-110) | Under: (-110)

The Colts enter this contest as a small home favorite on the moneyline and the spread. This Monday night clash also features one of the lower totals on the Week 12 slate at 39.5 points.

Steelers vs Colts Prediction & Pick

The Steelers and the Colts line up as very similar teams this year. On offense, they both roster an elite running back and tend to focus on establishing a ground game early on. On defense, they both rely on a veteran defensive line to keep opposing quarterbacks uncomfortable in the pocket all day long.

One area Pittsburgh has a leg up on the Colts is at head coach. Mike Tomlin has guided his squad to seven straight wins over Indianapolis, while Jeff Saturday is still adjusting to coaching in the NFL. The Colts have also lost nine of their last 10 games against an NFC North opponent. It's been a nightmare.

This is going to be a grueling and hard-fought game, but the Steelers always shine as underdogs.

Final Score Prediction: Steelers: 20 | Colts: 17

Steelers vs Colts Betting Trends

- Pittsburgh is 7-0 straight up in its last seven games against Indianapolis.
- The total has hit the under in four of Pittsburgh's last six games.
- Indianapolis is 1-9 straight up in its last 10 games against an AFC North opponent.
- The total has hit the over in six of Indianapolis' last eight games against Pittsburgh.

Steelers vs Colts Best Bet

Don't be surprised if the defensive line of the Steelers feasts on Monday night. The return of TJ Watt combined with the dependability of Cameron Heyward has transformed this group into one of the scariest in the NFL. The Colts have also allowed a sack on 8.9% of their QB dropbacks (No. 27 in NFL).

Veteran Matt Ryan cannot scramble out of the pocket with ease at 37 years of age. That is going to cost the Colts precious yards in this one. Overall, Pittsburgh is 5-1 against the spread (ATS) in its last six games against Indianapolis. The Colts are a 1-6 ATS in their last seven games as a favorite, too.

Bet: Pittsburgh Steelers +2.5 (-105)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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