Seahawks vs 49ers Prediction, Odds & Betting Trends for NFL Week 2 Game on FanDuel Sportsbook (Sept 18)

Seahawks vs 49ers Week 2 Game Info

2022 NFL Regular Season Game
Seattle Seahawks (1-0, 0-0 Away) vs. San Francisco 49ers (0-1, 0-0 Home)
Date: Sunday, Sept. 18, 2022
Time: 4:05 p.m. ET
Venue: Levi's Stadium— Santa Clara, CA
Coverage: FOX

Week 2 of the 2022 NFL season includes an NFC West showdown between the Seattle Seahawks and San Francisco 49ers. The Seahawks are riding high after ruining Russell Wilson's homecoming party and defeating the Denver Broncos, 17-16, on Monday. Quarterback Geno Smith completed 23-of-28 passes (82.1%) for 195 yards and a pair of touchdowns.

Meanwhile, the 49ers are feeling the complete opposite after a disappointing 19-10 opening-week loss to the Chicago Bears. Rain and poor field conditions were a factor in the loss, leaving time to tell if San Francisco can bounce back or if Kyle Shanahan's team is as bad as they looked last week.

Seahawks vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SEA: (+310) | SF: (-390)
Spread: SEA: +8.5 (-112) | SF: -8.5 (-108)
Total: 39.5 —Over: (-110) | Under: (-110)

Updated (Sunday, Sept. 18, 12:20 p.m. EST): The 49ers enter this contest as the heavy favorite on the moneyline and spread on FanDuel Sportsbook's updated odds. This 4:05 p.m. ET clash also features a total of 39.5, which moved down three points from the opening line and is now the second-lowest total on this week's slate.

Seahawks vs 49ers Prediction & Pick

Even though the 49ers are the odds-on favorites, they haven't had much success against the Seahawks lately. Seattle has won 17 of its last 20 meetings against its NFC West rival and has only lost one of its last 11 trips to San Francisco. Needless to say, a 49ers victory might not be as clear-cut as the odds imply.

Throw in Trey Lance's struggles under center and that starting running back Elijah Mitchell is sidelined, and there's reason to be concerned about San Francisco this week. While I think that the 49ers have the better overall roster, the Seahawks have a lot of heart and if the defense plays as well as it did in Week 1, this game could be closer than expected.

Final Score Prediction: 49ers: 20 | Seahawks: 16

Seahawks vs 49ers Betting Trends

- Seattle is 15-5 against the spread (ATS) in its last 20 games against San Francisco.
- San Francisco is 2-6 straight up in its last eight games against NFC West teams.
- The total has hit the under in nine of Seattle's last 13 road games.
- The total has hit the under in eight of San Francisco's last nine games.

Seahawks vs 49ers Best Bet

On top of consistently beating the 49ers up, the Seahawks also do well against the spread when their rivals are involved. An 8.5-point spread is too much for my liking after San Francisco's unimpressive Week 1 performance. Considering that the Seahawks are 15-5 ATS in their last 20 games against the 49ers, give me Seattle covering the spread.

Bet: Seahawks +8.5 (-112)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.