Seahawks vs 49ers Prediction, Odds & Best Bets for NFC Wild Card Playoff Game (Defenses Thrive in Santa Clara)

Larry Rupp
Seattle Seahawks vs San Francisco 49ers prediction, odds and best bets for NFC Wild Card Playoff game.
Seattle Seahawks vs San Francisco 49ers prediction, odds and best bets for NFC Wild Card Playoff game. / AP Photos/Marcio Jose Sanchez

Seahawks vs 49ers Wild Card Game Info

2022 NFL Playoffs — NFC Wild Card Game
Seattle Seahawks (9-8, 4-4 Away) vs. San Francisco 49ers (13-4, 8-1 Home)
Date: Saturday, Jan. 14, 2023
Time: 4:30 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: FOX

With the regular season in the rearview mirror, it is time for the NFL Playoffs to begin. The Seattle Seahawks will travel to take on the San Francisco 49ers to kick off Wild Card weekend on Saturday, Jan. 14. These NFC West foes have already met twice this year, with the 49ers winning both games.

Seattle is the No. 7 seed in the NFC and enters looking to prove people wrong. The Seahawks lost five of their last eight games of the regular season. Meanwhile, San Francisco is the No. 2 seed in the NFC and has its eyes set on winning it all. The 49ers are currently riding a great 10-game winning streak.

Seahawks vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SEA: (+380) | SF: (-500)
Spread: SEA: +10 (-110) | SF: -10 (-110)
Total: 42.5 — Over: (-114) | Under: (-106)
Odds to Win Super Bowl: SEA: +6500 | SF: +550

The 49ers enter this contest as clear home favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Saturday afternoon clash also features the lowest total on the Wild Card slate at 42.5 points.

Seahawks vs 49ers Prediction & Pick

These two teams have been defying the odds all season long. Quarterback Geno Smith was not expected to lead his squad to the playoffs, but then he set the franchise record for passing yards in a Seahawks season (4,282). This offense averages 380.8 total yards per away game (No. 4 in NFL).

All hope seemed lost for the 49ers when Trey Lance and Jimmy Garoppolo went down with injuries at the QB position. Rookie Brock Purdy has stepped in with poise, though, and San Francisco hasn't missed a beat. The Iowa State product has thrown 13 touchdowns compared to 4 interceptions.

When it comes down to it, the 49ers have the defense needed to win close games in January. San Francisco has posted the best total DVOA rating in the NFL and is allowing just 16.3 points per game (No. 1 in NFL). The 49ers held the Seahawks to a total of 20 points across two head-to-head games.

Final Score Prediction: Seahawks: 14 | 49ers: 24

Seahawks vs 49ers Betting Trends

- Seattle is 1-7 against the spread (ATS) in its last eight games.
- The total has hit the under in four of Seattle's last five games.
- San Francisco is 6-0 straight up in its last six games against an NFC West opponent.
- The total has hit the over in four of San Francisco's last five games as a favorite.

Seahawks vs 49ers Best Bet

As mentioned above, there's no team in the NFL that wants to face this 49ers defense in the playoffs. San Francisco is giving up only 5.0 yards per play (No. 4 in NFL) and has tallied 30 takeaways on the year (T-No. 2 in NFL). Trusting stars like Nick Bosa and Fred Warner to stand tall is the way to go here.

The way to do that is through backing a low-scoring game as San Francisco has held eight of their last 10 opponents to under 20 points. It's worth noting the total has also hit the under in four of Seattle's last five games overall, too. Expect two familiar teams to take some time to get going.

Bet: Under 42.5 Points (-106)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.