Saints vs 49ers Prediction, Odds & Best Bets for Week 12 (San Francisco Fails to Pull Away in the Second Half)

Saints vs 49ers Week 12 Game Info

2022 NFL Regular Season — Week 12
New Orleans Saints (4-7, 1-3 Away) vs. San Francisco 49ers (6-4, 3-1 Home)
Date: Sunday, Nov. 27, 2022
Time: 4:25 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: FOX

The San Francisco 49ers will look to remain atop the AFC West when they host the New Orleans Saints in Week 12 NFL action. The Saints enter off a 27-20 win over the Los Angeles Rams on Sunday. Quarterback Andy Dalton went 21-of-25 and logged 260 yards as well as 3 touchdowns.

Meanwhile, the 49ers shined in front of the Mexico City crowd in Week 11 and took down the Arizona Cardinals by a score of 38-10. Quarterback Jimmy Garoppolo tied a career-high mark with 4 touchdown passes, two of which went to tight end George Kittle. San Francisco has won three in a row.

Saints vs 49ers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NO: (+315) | SF: (-400)
Spread: NO: +8.5 (-110) | SF: -8.5 (-110)
Total: 43 — Over: (-110) | Under: (-110)

Updated (Sunday, Nov. 27, 11:50 a.m. EST): The 49ers enter this contest as a heavy home favorite on the moneyline and the spread on FanDuel Sportsbook's updated odds. This 4:25 p.m. ET clash also features one of the more average totals on the Week 12 slate at 43 points.

Saints vs 49ers Prediction & Pick

The 49ers have a chance to distance themselves from the Seattle Seahawks in the division if they can keep racking up wins. They have a perfect opportunity to do just that on Sunday. The Saints rank outside the top 20 NFL teams in terms of rushing yards allowed per game (132.1) and per carry (4.6).

That bodes well for the backfield duo of Christian McCaffrey and Elijah Mitchell. Each running back is averaging at least 4.6 yards per carry on the year, while they have also combined for 330 total yards over the last two games. It's a big reason why San Francisco ranks 11th in total offense DVOA rating.

The 49ers are 7-1 straight up in their last eight home games, so I'll back Garoppolo & company.

Final Score Prediction: Saints: 20 | 49ers: 27

Saints vs 49ers Betting Trends

- New Orleans is 9-4 straight up in its last 13 games against San Francisco.
- The total has hit the over in six of New Orleans' last eight games against San Francisco.
- San Francisco is 12-6 against the spread (ATS) in its last 18 games.
- The total has hit the under in 13 of San Francisco's last 18 games.

Saints vs 49ers Best Bet

The 49ers will likely sneak out of Levi's Stadium with a win on Sunday, but don't expect it to be easy. The Saints have been much more competitive than their 4-7 record indicates. Keep in mind New Orleans ranks seventh in yards per play (5.8) and first in passing plays of 40 or more yards (10).

The Saints can move the ball down the field and also keep opponents from scoring. New Orleans allows an opponent red zone scoring percentage of just 48.4% (No. 5 in NFL). Each of the last five games between the Saints & 49ers has resulted in a one-possession loss or outright win for New Orleans.

Bet: New Orleans Saints +8.5 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.