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Phillies vs Astros Prediction, Odds, Betting Trends & Probable Pitchers for 2022 MLB World Series Game 6

Larry Rupp
Philadelphia Phillies vs Houston Astros prediction, odds, betting trends and probable pitchers for 2022 MLB World Series Game 6.
Philadelphia Phillies vs Houston Astros prediction, odds, betting trends and probable pitchers for 2022 MLB World Series Game 6. / AP Photos/David J. Phillip
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Phillies vs Astros Game 6 Info

2022 MLB Playoffs — World Series Game 6 (HOU Leads 3-2)
Philadelphia Phillies (87-75, 40-41 Away) vs. Houston Astros (106-56, 55-26 Home)
Date: Saturday, November 5, 2022
Time: 8:03 p.m. ET
Venue: Minute Maid Park — Houston, TX
Coverage: FOX

The 2022 World Series has been anything but a cakewalk for the favored Houston Astros. They found themselves in a 2-1 series hole before winning back-to-back road games against the Philadelphia Phillies. Pitcher Justin Verlander captured his first win in the fall classic during a 3-2 Game 5 victory.

Minute Maid Park will surely be rocking on Saturday night, but Houston has only earned the win in four of its last 10 World Series home games. Can the Phillies force a winner-take-all with a bounce back performance in Game 6? Or will the Astros win the title for the second time in franchise history?

Phillies vs Astros Odds & Spread

All MLB postseason betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PHI: (+126) | HOU: (-148)
Spread: PHI: +1.5 (-178) | HOU: -1.5 (+146)
Total: 7 — Over: (+102) | Under: (-124)

The Astros enter this contest as a slight home favorite on the moneyline and spread. They are listed at -148 moneyline odds with +155 odds to cover the 1.5-run spread. The over/under on this matchup features 7 runs, with the under being favored at -115 odds.

Phillies vs Astros Prediction & Pick

Astros fans have to be feeling good about their team's position as Framber Valdez is set to take the mound for Game 6. The 28-year-old picked apart the Phillies in Game 2, striking out 9 batters and giving up 1 run in 6.1 innings. Valdez has now allowed only 3 earned runs across 19.0 playoff innings.

The Phillies will counter with their ace, Zack Wheeler. Wheeler looked fatigued in Game 2 and allowed 5 runs (4 earned) on 6 hits and 3 walks across 5.0 innings. His velocity was down, so manager Rob Thomson decided to give him an extra day of rest this week. It'll be interesting to see if that helps.

All of the momentum is on the side of the Astros right now. After all, first baseman Trey Mancini and outfielder Chas McCormick each made outstanding defensive plays on Thursday night to seal the win. Philadelphia is also ice cold at the plate, scoring only 2 runs across the last 21.0 innings of play.

It's hard to go against Valdez. Another big performance could earn him World Series MVP honors.

Final Score Prediction: Phillies: 3 | Astros: 4

Phillies vs Astros Probable Starting Pitchers

Philadelphia will look to Zack Wheeler (12-7, 2.82 ERA) in Game 6 while Houston will hand the ball to Framber Valdez (17-6, 2.82 ERA).

Phillies vs Astros Betting Trends

- Philadelphia is 2-5 straight up in its last seven away games against Houston.
- The total has hit the under in four of Philadelphia's last six games against Houston.
- Houston is 7-1 straight up in its last eight home games.
- The total has hit the under in eight of Houston's last 11 games.

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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