Patriots vs Cardinals Prediction, Odds & Best Bets for Monday Night Football (Pats Fall Short in Primetime)

Patriots vs Cardinals Week 14 Game Info

2022 NFL Regular Season — Week 14
New England Patriots (6-6, 3-3 Away) vs. Arizona Cardinals (4-8, 1-6 Home)
Date: Monday, Dec. 12, 2022
Time: 8:15 p.m. ET
Venue: State Farm Stadium — Glendale, AZ
Coverage: ESPN

Two teams on the playoff bubble will fight to keep their postseason hopes alive on Monday Night Football in Week 14. The New England Patriots have slipped to last place in the AFC East at 6-6, while the Arizona Cardinals are hanging on by a thread at 4-8.

The Patriots are coming off back-to-back losses after falling to the Buffalo Bills at home in Week 13, while the Cardinals had also lost two in a row prior to their Week 13 bye. With both teams in desperate need of a win, which one will bounce back in Week 14?

Patriots vs Cardinals Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NE: (-124) | ARZ: (+106)
Spread: NE: -1.5 (-108) | ARZ: +1.5 (-112)
Total: 44.5 — Over: (-110) | Under: (-110)

Despite their recent struggles, the Patriots enter this game as slight road favorites on both the moneyline and the spread. This primetime matchup also features a total of 44.5 points, which is about average compared to other totals on the Week 14 slate.

Patriots vs Cardinals Prediction & Pick

Just when the Patriots seemed to be picking up steam, they faltered as they reached the hard part of their schedule. Week 13's loss to Buffalo was particularly ugly, as New England managed just 10 points and 242 total yards of offense.

The Patriots have now lost all three of their games in primetime this year, two of which were decided by multiple touchdowns. For whatever reason, New England just hasn't looked ready for these important matchups, but perhaps a few extra days off will help.

The Cardinals have been a tough team to pin down this year, as they've been wildly inconsistent from week to week. They've also been surprisingly terrible at home, dropping their last three games at State Farm Stadium.

Injuries and suspensions to key offensive players like DeAndre Hopkins, James Conner and Hollywood Brown have contributed to those issues, but Arizona should be healthier now coming off its bye week. The Patriots have a better defense but the Cardinals on superior on offense, which should help them pull out a close win at home here.

Final Score Prediction: Cardinals: 20 | Patriots: 17

Patriots vs Cardinals Betting Trends

- New England is 0-4 straight up in its last 4 primetime games.
- Arizona is 3-9 against the spread (ATS) in its last 12 home games.
- The total has gone over in Arizona's last six games overall.
- The total has gone under in four of New England's last five games against Arizona.

Patriots vs Cardinals Best Bet

New England's defense will do enough to keep Arizona's offense in check for the most part, but at the end of the day the Patriots haven't proven that they can keep up with superior offenses. Their lack of playmakers, questionable playcalling and mediocre passing attack will make it difficult to keep pace with Kyler Murray and all the weapons at his disposal, especially on the road.

Bet: Arizona Cardinals +1.5 (-112)

Game odds refresh periodically and are subject to change.