Patriots vs Browns Prediction, Odds & Betting Trends for NFL Week 6 Game on FanDuel Sportsbook (Oct 16)

Patriots vs Browns Week 6 Game Info

2022 NFL Regular Season — Week 6
New England Patriots (2-3, 1-2 Away) vs. Cleveland Browns (2-3, 1-1 Home)
Date: Sunday, October 16, 2022
Time: 1:00 p.m. ET
Venue: FirstEnergy Stadium — Cleveland, OH
Coverage: CBS

The Cleveland Browns will aim to end a two-game skid when they host the New England Patriots in Week 6 NFL action. The Patriots relied on their veteran defense to secure a 29-0 win over the Detroit Lions in Week 5. Running back Rhamondre Stevenson paced the offense with 161 yards on 25 carries.

Meanwhile, the Browns found themselves on the wrong end of a back-and-forth battle against the Los Angeles Chargers on Sunday. A missed field goal by kicker Cade York with only 16 seconds left on the clock has to leave a sour taste in Cleveland fans' mouths in what ended up being a 30-28 loss.

Patriots vs Browns Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NE: (+134) | CLE: (-158)
Spread: NE: +3 (-110) | CLE: -3 (-110)
Total: 42.5 — Over: (-110) | Under: (-110)

The Browns enter this contest as a small home favorite on the moneyline and the spread. This 1:00 p.m. ET clash also features one of the lower totals on the Week 6 slate at 42.5 points.

Patriots vs Browns Prediction & Pick

Momentum is going in opposite directions when it comes to these two teams. New England flexed its defensive muscles in Week 5 and got the job done with third-string quarterback Bailey Zappe leading the way. The players have to feel like there is a chance to turn the season around in the AFC East now.

The Browns suffered another gut punch, though. All three of Cleveland's losses have come by three points or fewer. Returning home gives them an opportunity to bounce back, but I side with the Patriots here. Head coach Bill Belichick knows how to beat the Browns, posting an 8-1 record in nine meetings.

Final Score Prediction: Patriots: 21 | Browns: 20

Patriots vs Browns Betting Trends

- New England is 8-1 straight up in its last nine games against Cleveland.
- The total has hit the over in six of New England's last nine games.
- Cleveland is 2-6 against the spread (ATS) in its last eight home games.
- The total has hit the over in five of Cleveland's last seven games against New England.

Patriots vs Browns Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

Diving into the statistics make a New England upset victory seem even more likely here. The Patriots are not only 8-1 in their last nine games against the Browns, but they are also 7-2 against the spread (ATS) during that same span. New England notably crushed Cleveland by a score of 45-7 last season.

Keep in mind New England doesn't have to win the game to cover the spread here, either. All it has to do is keep the final score within a field goal. The Browns have only beaten an opponent by more than 2 points once this season. I'll take the Patriots in Week 6, no matter who the starting quarterback is.

Bet: New England Patriots +3 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.