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Panthers vs Rams Prediction, Odds & Betting Trends for NFL Week 6 Game on FanDuel Sportsbook (Oct 16)

Larry Rupp
Carolina Panthers vs Los Angeles Rams prediction, odds and betting trends for NFL Week 6 game.
Carolina Panthers vs Los Angeles Rams prediction, odds and betting trends for NFL Week 6 game. / AP Photos/Marcio Jose Sanchez
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Panthers vs Rams Week 6 Game Info

2022 NFL Regular Season — Week 6
Carolina Panthers (1-4, 0-1 Away) vs. Los Angeles Rams (2-3, 1-2 Home)
Date: Sunday, October 16, 2022
Time: 4:05 p.m. ET
Venue: SoFi Stadium — Inglewood, CA
Coverage: FOX

The Carolina Panthers will look to pull off a major road upset when they visit the Los Angeles Rams in Week 6 NFL action. The Panthers have lost their last two games by a combined 32 points and recently fired head coach Matt Rhule. Things are starting to unravel for Carolina in a massive way.

Meanwhile, the Rams are on a two-game skid of their own after losing to the Dallas Cowboys in Week 5 by a score of 22-10. LA was forced to rely on the air attack after falling into an early hole and it did not work out. On defense, LA was gashed on the ground and allowed a whopping 5.5 yards per carry.

Panthers vs Rams Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: CAR: (+380) | LAR: (-490)
Spread: CAR: +10.5 (-115) | LAR: -10.5 (-105)
Total: 40.5 — Over: (-110) | Under: (-110)

The Rams enter this contest as a heavy home favorite on the moneyline and the spread. This 4:05 p.m. ET clash also features one of the lower totals on the Week 6 slate at 40.5 points.

Panthers vs Rams Prediction & Pick

The Rams certainly don't look like the same team that won the Super Bowl last season. With that being said, this lines up as the perfect bounce back opportunity. Keep in mind the Panthers will be without their starting quarterback in Baker Mayfield on Sunday as he tends to a high ankle sprain.

Carolina has earned just one win over it last 11 games dating back to the 2021 season. The Panthers are also averaging a league-low 271.4 yards per game as well as only 4.9 yards per play (T-No. 26 in NFL). Veteran defenders like Aaron Donald and Bobby Wagner should wreak havoc on QB PJ Walker.

Final Score Prediction: Panthers: 10 | Rams: 27

Panthers vs Rams Betting Trends

- Carolina is 0-5 against the spread (ATS) in its last five away games.
- The total has hit the under in five of Carolina's last seven games against the Rams.
- The Rams are 5-0 straight up in its last five games against a NFC South opponent.
- The total has hit the under in six of the Rams' last seven games.

Panthers vs Rams Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

There's a lot to like about the Rams' chances of blowing out the Panthers in Week 6. Carolina is a dismal 1-11 against the spread (ATS) in its last 12 games and will have an interim head coach in Steve Wilks manning the sideline on Sunday. Time is going to be needed for both him and Walker to adjust.

Sean McVay knows the importance of getting back on the right track, too. LA's next two matchups following this one come against the San Francisco 49ers and Tampa Bay Buccaneers. Entering those games with a losing record would be a nightmare, so it's do-or-die time for QB Matthew Stafford.

Bet: Los Angeles Rams -10.5 (-105)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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