Panthers vs Giants Prediction, Odds & Betting Trends for NFL Week 2 Game on FanDuel Sportsbook (Sept 18)

Devon Platana
Carolina Panthers vs New York Giants prediction, odds and betting trends for NFL regular season game.
Carolina Panthers vs New York Giants prediction, odds and betting trends for NFL regular season game. / AP Photo/Mark Zaleski
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Panthers vs Giants Week 2 Game Info

2022 NFL Regular Season Game
Carolina Panthers (0-1, 0-0 Away) vs. New York Giants (1-0, 0-0 Home)
Date: Sunday, Sept. 18, 2022
Time: 1 p.m. ET
Venue: MetLife Stadium — East Rutherford, NJ
Coverage: FOX

Week 2 of the 2022 NFL season includes a showdown between the Carolina Panthers and New York Giants. The Baker Mayfield-led Panthers couldn't get it done against his former team last week, losing 26-24 to the Cleveland Browns. Mayfield's performance wasn't anything crazy, throwing for 235 yards and a touchdown with an interception while also rushing the ball into the end zone once.

Meanwhile, the Giants did find success in a 21-20 upset win over the Tennessee Titans. Head coach Brian Daboll's presence had a positive impact on running back Saquon Barkley, who racked up 164 yards and a TD on 18 carries.

Panthers vs Giants Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: CAR: (-116) | NYG: (-104)
Spread: CAR: -1 (-110) | NYG: +1 (-110)
Total: 43.5 — Over: (-118) | Under: (-104)

Updated (Sunday, Sept. 18, 12:30 p.m. EST): Updated odds were provided from FanDuel Sportsbook. The odds completed flipped in this matchup. Carolina was previously a 2.5-point road underdog, but is now the 1-point favorite. The over/under point total climbed to 43.5 points.

The Giants enter this contest as the favorite on the moneyline and the spread. This 1 p.m. ET clash also features a total of 42.5, which is somewhat low compared to this week's NFL projected totals.

Panthers vs Giants Prediction & Pick

Out of the two teams, it was the Giants that had the more impressive effort last week. It helps that Barkley finally looks like his old self while Daniel Jones was competent under center. Meanwhile, the Panthers were asleep for the first three quarters, entering the fourth quarter against the Browns down 20-3.

If the Panthers come out with a similar effort this week, they'll be in trouble. The Giants seem more structured under Daboll and aren't making as many mistakes as in previous years. Even if it's only a small sample size, I like more of what I saw from New York than Carolina in Week 1.

Unless the Panthers start stronger and actually utilize Christian McCaffrey, I'm expecting the Giants to start the 2022 campaign with a 2-0 record.

Final Score Prediction: Giants: 28 | Panthers: 21

Panthers vs Giants Betting Trends

- Carolina is 0-8 straight up in its last eight games.
- The Giants are 5-1 against the spread (ATS) in their last six games against Carolina.
- The total has hit the over in four of Carolina's last five road games against the Giants.
- The total has hit the over in each of the Giants' last five home games.

Panthers vs Giants Best Bet

With the Giants' impressive performance last week combined with their recent spread success against the Panthers, covering the 2.5-point spread shouldn't be an issue. It also helps that Carolina is an abysmal 0-8 ATS in its last eight games.

Bet: Giants -2.5 (-108)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

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