Ole Miss vs Vanderbilt Prediction, Odds & Betting Trends for College Football Game on FanDuel Sportsbook

Mississippi vs Vanderbilt Week 6 Game Info

2022 NCAA College Football Game
No. 9 Ole Miss Rebels (5-0, 1-0 SEC) vs. Vanderbilt Commodores (3-2, 0-1 SEC)
Date: Saturday, Oct. 8, 2022
Time: 4 p.m. ET
Venue: FirstBank Stadium — Nashville, TN
Coverage: SEC Network

Week 6 of the 2022 NCAA college football season includes an SEC cross division match-up between the No. 9 Ole Miss Rebels and Vanderbilt Commodores. Mississippi is 5-0, and one of four undefeated SEC teams following last week's escape against Kentucky, 22-19 in their first conference game of the season.

Meanwhile, Vanderbilt plays at home for the first time in a month. The Commodores are off a bye week having lost to No. 1 Alabama 55-3 to close out September.

Mississippi vs Vanderbilt Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: MISS: (-880) | VAN: (+570)
Spread: MISS: -16.5 (-115) | VAN: +16.5 (-105)
Total: 61.5 — Over: (-114) | Under: (-108)

Ole Miss is a big favorite on the spread (-16.5) and moneyline (-880). The spread is down a few points from the opener Sunday night. An outright win by Vanderbilt returns +570 on the moneyline. The total is higher at 61.5 points, and has been bet higher from the opener.

Mississippi vs Vanderbilt Prediction & Pick

Ole Miss ranks Top 20 in the country in yards per play, yards per game and points per game margin. Against four FBS opponents, the Rebels are averaging 460 yards per game including 269 rushing yards per game led by freshman Quinshon Judkins (535 yards) and TCU transfer Zach Evans (389). Last week against a stern Kentucky defense, Ole Miss rushed for 186 yards and passed for 213 yards. The Rebels defense held Kentucky QB Will Levis to 220 passing yards - 60 below his season average. The Ole Miss defense has made major strides this season, but does come off a grinding, physical win against Kentucky. The week prior, Ole Miss allowed 262 rushing yards to Tulsa at more than 6.0 yards per rush.

OIe Miss has fumbled the ball 12 times and lost three. The Vandy defense has forced a turnover in a FBS high 14 straight games. Against a sub-par Wake Forest defense, Vanderbilt could only manage 294 yards while allowing 450 in a 45-25 defeat. An extra week of rest and prep should have the Vanderbilt offense ready to show more, but they still won't keep pace.

Final Score Prediction: Ole Miss : 42 | Vanderbilt: 20

Mississippi vs Vanderbilt Betting Trends

- Ole Miss is 5-0 straight up (SU) in their 5 games this season.
- Ole Miss is 2-4 against the spread (ATS) in their last 6 games.
- The total has gone Under in 5 of Ole Miss' last 5 road games.
- Vanderbilt is 5-15 SU in their last 20 games.
- Vanderbilt is 2-12 SU in their last 14 home games.
- Vanderbilt is 6-3 ATS in their last 9 games.

Mississippi vs Vanderbilt Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

ESPN's Football Power Index gives Ole Miss a 89.6% chance to win based on the big point spread. Last year, the Rebels were also ranked top-10 when they played Vanderbilt late in the season and only won 31-17 laying 36 points. Now the spread is more than cut in half, but Vanderbilt has a situational scheduling edge.

The line has dipped down, and Ole Miss may not be at their best this week and also have a redemption rematch with Auburn next week. But the Rebels offense may enjoy ripping through a 'Dores defense that was picked apart by their only two quality offenses while allowing 55 and 45 points to Alabama and Wake Forest.

Bet: Ole Miss -16.5 (-115)

Game odds refresh periodically and are subject to change.