Notre Dame vs USC Prediction, Odds & Best Bet for Week 13 (Elite Offenses Meet in West Coast Shootout)

Notre Dame vs USC Week 13 Game Info

2022 NCAA College Football Game
No. 18 Notre Dame Fighting Irish (8-3) vs. No. 7 USC Trojans (10-1)
Date: Saturday, Nov. 26, 2022
Time: 7:30 p.m. ET
Venue: Los Angeles Memorial Coliseum — Los Angeles, CA
Coverage: ABC

Week 13 of the 2022 college football season includes a rivalry matchup between the No. 18 Notre Dame Fighting Irish and No. 7 USC Trojans. Notre Dame has now ripped off five victories in a row, including a 44-0 win over Boston College on Saturday. Running back Audric Estime scored twice.

Meanwhile, USC relied on its offense to earn a 48-45 win over UCLA in Week 12. Quarterback Caleb Williams shined with 470 passing yards, 33 rushing yards and 3 total touchdowns (1 interception). Defensive back Mekhi Blackmon and linebacker Shane Lee each nabbed an interception on defense.

Notre Dame vs USC Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: ND: (+168) | USC: (-205)
Spread: ND: +5.5 (-110) | USC: -5.5 (-110)
Total: 62.5 — Over: (-110) | Under: (-110)

USC enters this contest as a notable home favorite on the moneyline and the spread. This Saturday night clash also features a total of 62.5 points, which is above average compared to this week's college football projected totals.

Notre Dame vs USC Prediction & Pick

Notre Dame has a chance to play spoiler on Saturday in a season in which things have started to turn around. Wins over Syracuse and Clemson show that this team still rosters a core capable of beating any team. Traveling across the country to face a top-10 squad is about as tough as it gets, though.

USC has all of the momentum on it side heading into this one as a spot in the College Football Playoff is well within reach. The Trojans are led by a Heisman candidate in Williams and also boast a backfield that averages 183.3 rushing yards per game. There's too much talent for the Fighting Irish to keep up.

The Trojans are 6-0 straight up in their last six home games and I trust them to get the job done here.

Final Score Prediction: Notre Dame: 31 | USC: 35

Notre Dame vs USC Betting Trends

- Notre Dame is 5-1 straight up in its last six games against USC.
- The total has hit the over in each of Notre Dame's last five games.
- USC is 4-2 against the spread (ATS) in its last six games.
- The total has hit the over in each of USC's last five games.

Notre Dame vs USC Best Bet

This game could go either way, so the betting value lies in the point total. Both Notre Dame and USC are averaging at least 39.8 points per game over the last five weeks. The Trojans have also allowed an opponent to score at least 35 points in four of those five games. They are born to play in shootouts.

The total has hit the over in each of USC's last five games as well as in five of its last six games played in November. The over has also cashed in each of Notre Dame's last five games. With Williams, Estime, Jordan Addison and Michael Mayer all on the same field, back a ton of points to be scored.

Bet: Over 62.5 Points (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.