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Notre Dame vs Ohio State Prediction, Odds & Betting Trends for College Football Week 1 Game on FanDuel (Sept 3)

Devon Platana
Notre Dame vs. Ohio State prediction, odds and betting trends for NCAA college football game.
Notre Dame vs. Ohio State prediction, odds and betting trends for NCAA college football game. / AP Photo/Jay LaPrete
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Notre Dame vs Ohio State Week 1 Game Info

2022 NCAA College Football Game
No. 5 Notre Dame Fighting Irish (0-0, 0-0) vs. No. 2 Ohio State Buckeyes (0-0, 0-0)
Date: Saturday, Sept. 3, 2022
Time: 7:30 p.m. ET
Venue: Ohio Stadium — Columbus, OH
Coverage: ABC

Week 1 of the 2022 NCAA college football season includes a showdown between the No. 5 Notre Dame Fighting Irish and No. 2 Ohio State Buckeyes. The Fighting Irish are set to embark on Marcus Freeman's first full season as the head coach after going 11-2 last season, ending the year with a 37-35 loss to Oklahoma State at the Fiesta Bowl.

On paper, Ohio State had a great year that included an 11-2 record, as well as a 48-45 Rose Bowl victory over the Utah Utes. Unfortunately, things could've been much better for the Buckeyes had they not missed their first College Football Playoff since 2018 after losing games to both Michigan and Oregon. Now, OSU is poised to bounce back this fall.

Notre Dame vs Ohio State Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: ND: (+520) | OSU: (-750)
Spread: ND: +17.5 (-120) | OSU: -17.5 (-102)
Total: 59.5 — Over: (-105) | Under: (-115)

Ohio State enters this contest as the favorite on the moneyline and the spread. This 7:30 p.m. ET clash also features a total of 59.5, which is higher than most of this week's college football projected totals.

Notre Dame vs Ohio State Prediction & Pick

While Notre Dame and Ohio State have only met six times over the years, history solidifies why the Buckeyes are favorites this week. After all, OSU has won each of the last four meetings between the two schools, with the most recent victory coming in the form of a 44-28 win back in 2015.

The Fighting Irish are a solid squad, but this is the Buckeyes that we're talking about. The CJ Stroud-led offense averaged the most points (45.7) and yards (561.5) in 2021 and even though Notre Dame had a top-20 defense, it likely won't be able to keep up with OSU's 60-minute attack.

Final Score Prediction: Ohio State: 42 | Notre Dame: 24

Notre Dame vs Ohio State Betting Trends

- Notre Dame is 9-2 against the spread (ATS) in its last 11 games played on Saturday.
- Ohio State is 7-0 straight up in its last seven games against Independent schools.
- The total has hit the over in four of Notre Dame's last six games played in September.
- The total has hit the over in each of Ohio State's last five Week 1 matchups.

Notre Dame vs Ohio State Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Regardless of which school you think will win, both Notre Dame and Ohio State will likely look for a big start to solidify their status as top-25 schools. There's a ton of potential here for this game to turn into a shootout and if either team's September trends are anything to go by, this game will be a barn-burner.

Bet: Over 59.5 Points (-105)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

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