Louisville vs Boston College Prediction, Odds & Betting Trends for College Football Game on FanDuel Sportsbook

Updated: Sep 10, 5:00pm UTC

Louisville vs Boston College Week 5 Game Info

2022 NCAA College Football Game
Louisville Cardinals (2-2, 0-2 ACC) vs. Boston College (1-3, 0-2 ACC)
Date: Saturday, Oct. 1, 2022
Time: 12:00 p.m. ET
Venue: Alumni Stadium -- Chestnut Hill, MA
Coverage: ESPN

Week 5 of the 2022 NCAA college football season includes an ACC matchup between the Louisville Cardinals and Boston College Eagles, who are a big home underdog.

Both teams are 0-2 in the ACC Atlantic division and Boston College is 0-4 ATS this season.

Louisville vs Boston College Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LOU: (-690) | BC: (+480)
Spread: LOU: -15.5 (-110) | BC: +15.5 (-110)
Total: 50.5 — Over: (-115) | Under: (-105)

Louisville opened as an 11-point favorite on Sunday in Las Vegas, and the spread is now up to -15.5 with the moneyline heavily favoring the Cardinals at -690. The total sits at 50.5 points, which is below the average projected total this week.

Louisville vs Boston College Prediction & Pick

It's been a real struggle for Boston College as their power rating and performance continues to decline. The Eagles' lone win was over FCS Main, but BC has lost their last two ACC contests. The first was a 27-10 defeat at Virginia Tech, followed by a 44-14 drubbing at Florida State last week. BC is 0-4 ATS this season, and bettors are circling like vultures to bet against the Eagles.

Louisville lost to Florida State two weeks ago, 35-31, despite rushing (252) and passing (243) for big yardage. Three turnovers were costly in defeat, but the Cardinals bounced back big last week with a 41-3 smackdown of South Florida with a similarly balanced rushing and passing attack.

Final Score Prediction: Louisville: 34 | Boston College: 13

Louisville vs Boston College Betting Trends

- Louisville is 3-9 straight up (SU) in their last 12 road games.
- Louisville is 1-4 against the spread (ATS) in their last 5 games vs Boston College.
- Louisville is 2-4 SU/ATS in their last 6 games.
- Boston College is 1-5 SU and 0-6 ATS in their last 6 games.
- The total has gone under in 9 of BC's last 12 games.

Louisville vs Boston College Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Boston College is averaging 15 points per game against 3 FBS opponents this season and battered QB Phil Jurkovec has been sacked 14 times by a rebuilt offensive line. More struggles look likely with the Louisville defense already racking up 13 sacks.

Cardinals QB Malik Cunningham has been a dynamic dual-threat, rushing for 395 yards and 6 TDs on the ground while throwing for 776 passing yards. After beating BC by 14 points last year, Louisville should cruise to another easy win here.