Liverpool vs Real Madrid Prediction, Odds & Best Bet for Champions League Match (Top Goalscorers Shine at Anfield)

Larry Rupp
Liverpool vs Real Madrid prediction, odds and betting insights for Champions League match.
Liverpool vs Real Madrid prediction, odds and betting insights for Champions League match. / AP Photos/Jon Super
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Liverpool vs Real Madrid Match Info

2022-23 UEFA Champions League — Round of 16 (1st Leg)
Liverpool vs. Real Madrid
Date: Tuesday, Feb. 21, 2023
Time: 3:00 p.m. ET
Venue: Anfield — Liverpool, England

Liverpool and Real Madrid meet head-to-head in exciting Champions League action on Tuesday, Feb. 21. This Round of 16 matchup will take place across two legs to determine which team will advance to the next stage. Each team will get a chance to play in front of its home crowd, with Liverpool up first.

Liverpool vs Real Madrid Odds & Spread

All Champions League betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LIV: (-105) | REAL: (+250) | Draw (+290)
Spread: LIV: -1 (+250) | REAL: +1 (-125)
Total: 2.5 – Over: (-162) | Under: (+132)
Team to Score the First Goal: LIV: (-165) | REAL: (+130) I NO GOALS: (+1500)

Liverpool enters this contest as a clear home favorite on FanDuel Sportsbook's odds. This 3 p.m. ET clash also features an over/under of 2.5 goals with the over being favored at -162 odds.

Liverpool vs Real Madrid Prediction & Pick

Liverpool relied on its offensive attack to get the job done in group play, averaging a solid 2.8 goals on 17.0 shots per match. Mohamed Salah led the way, as he usually does, with 7 goals across the six matches. He also added 1 assist and remains one of the most dangerous players in men's soccer.

Real Madrid has emerged victorious in four of the last five times these teams have met in Champions League play, but winning in Anfield this time around is going to be difficult. Manager Jurgen Klopp will ensure his players know what leaving home with anything but a win would toughen the road ahead.

Salah will find enough gaps in Real Madrid's defense and score an exciting late winner for the Reds.

Final Score Prediction: Liverpool: 2 | Real Madrid: 1

Liverpool vs Real Madrid Betting Trends

- Real Madrid is 4-1-0 (W-D-L) in its last five matches against Liverpool.
- Liverpool finished second in Group A of the Champions League with a 5-0-1 (W-D-L) record.
- Real Madrid finished first in Group F of the Champions League with a 4-1-1 (W-D-L) record.

Liverpool vs Real Madrid Best Bet

Backing Liverpool to win is risky given Real Madrid's recent dominance in the head-to-head series, so shifting gears to the total is a smart move here. More than 2.5 goals were scored in four of Liverpool's six group-stage matches as well as in four of Real Madrid's six group-stage matches. Trust the trend.

Bet: Over 2.5 Goals (-162)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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