Jaguars vs Colts Opening Odds, Betting Lines & Prediction for Week 6 Game on FanDuel Sportsbook

Updated: Sep 10, 5:00pm UTC

Week 5 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 6, giving us an early preview of next week's slate.

Week 6's 1 p.m. slate sets up an exciting divisional matchup between the Jacksonville Jaguars and Indianapolis Colts.

Jaguars vs Colts Odds & Lines Week 6

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: JAC: (-104) | IND: (-112)
Spread: JAC: -1 (-110) | IND: +1 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

The Colts return home as a slight favorite against the Jaguars in Week 6. Indianapolis is an early -112 moneyline favorite, but is not favored on the spread.

Jaguars vs Colts Prediction Week 6

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
Jaguars: 49.4% to win
Colts: 50.0% to win

This game could come down to a few plays in the fourth quarter, according to the opening betting lines. ESPN's FPI seems to also think this game is a toss-up and I agree.

Both of these teams are in contention for the AFC South title and have been up and down in 2022. Give me the team with the better offensive line in the Jaguars. The Colts are letting quarterback Matt Ryan get sacked far too frequently, which is resulting in stalled drives and costly turnovers. Head coach Doug Pederson will get the rebuilding Jags back on track here. Bet Jacksonville on the moneyline (-104).

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.