Jaguars vs Chargers Prediction, Odds & Betting Trends for NFL Week 3 Game on FanDuel Sportsbook (Sept 25)

Jaguars vs Chargers Week 3 Game Info

2022 NFL Regular Season — Week 3
Jacksonville Jaguars (1-1, 0-1 Away) vs. Los Angeles Chargers (1-1, 1-0 Home)
Date: Sunday, September 25, 2022
Time: 4:05 p.m. ET
Venue: SoFi Stadium — Inglewood, CA
Coverage: CBS

Two teams looking to get above the .500 mark meet head-to-head in Week 3 as the Los Angeles Chargers host the Jacksonville Jaguars. The Jaguars dismantled the Indianapolis Colts in Week 2 by a score of 24-0 while putting on a masterful defensive performance (5.0 sacks, 3 interceptions).

Meanwhile, the Chargers dropped a close game on the road to the Kansas City Chiefs, 27-24, during Thursday Night Football. Los Angeles was up by a field goal entering the fourth quarter before an ugly pick six thrown by Justin Herbert turned the game on its head. Herbert also suffered a concerning rib injury in the game.

Jaguars vs Chargers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: JAC: (+164) | LAC: (-196)
Spread: JAC: +3.5 (-110) | LAC: -3.5 (-110)
Total: 42.5 — Over: (-115) | Under: (-105)

Updated (Sunday, Sept. 25, 12:30 p.m. ET): Odds for this game have shifted significantly with the Chargers plagued by injuries. LA has gone from a 7-point opening favorite to just 3.5 now. The Jaguars have improved on the moneyline from +275 to +164 now. The total has also fallen from 47.5 to just 42.5.

The Chargers enter this contest as a clear favorite on the moneyline and the spread. This 4:05 p.m. ET clash also features one of the higher projected totals (47.5) on the NFL Week 3 slate.

Jaguars vs Chargers Prediction & Pick

The health of Herbert is what Chargers fans should be keeping an eye on this week. Early reports suggest he will be able to suit up and if that is the case, Los Angeles should be able to pull out a victory. The Jaguars own a dismal 1-8 record in their last nine matchups against the Chargers.

Keep in mind that Herbert went 27-of-43 for 347 yards and 3 touchdowns the last time he faced off against Jacksonville in October of 2020. The third-year pro has improved his game a lot since then, which has to be scary for Jacksonville's defense. He is the difference-maker in this contest.

Final Score Prediction: Chargers: 28 | Jaguars: 21

Jaguars vs Chargers Betting Trends

- Jacksonville is 2-8 against the spread (ATS) in its last 10 games.
- The total has hit the under in 13 of Jacksonville's last 19 games.
- The Chargers are 8-1 straight up in their last nine games against Jacksonville.
- The total has hit the over in five of the Chargers' last six games against Jacksonville.

Jaguars vs Chargers Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

Watching to see if this spread moves in either direction throughout the week is going to be crucial for bettors. Anything under a touchdown would be great territory to back LA in front of the home crowd. The Chargers are a stellar 9-0 against the spread (ATS) in their last nine games against the Jaguars.

Jacksonville's offense has shown a ton of improvement under head coach Doug Pederson, but the defense is nowhere near ready to face a powerful offense like Los Angeles. LA has weapons all over the field, including running back Austin Ekeler and wide receiver Mike Williams. It's just too much talent for the Jags to handle.

Bet: Los Angeles Chargers -7 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.