Iowa State vs Kansas Prediction, Odds & Betting Trends for College Football Week 5 Game on FanDuel Sportsbook

Iowa State vs Kansas Week 5 Game Info

2022 NCAA College Football Game
Iowa State Cyclones (3-1, 0-1 Big 12) vs. Kansas Jayhawks (4-0, 1-0 Big 12)
Date: Saturday, Oct. 1, 2022
Time: 3:30 p.m. ET
Venue: David Booth Kansas Memorial Stadium — Lawrence, KS
Coverage: ESPN2

Week 5 of the 2022 NCAA college football season includes a Big 12 showdown between the Iowa State Cyclones and Kansas Jayhawks. Iowa State fell short in Week 4 for the first time this season in a 31-24 loss to the Baylor Bears as quarterback Hunter Dekkers threw a pair of costly interceptions.

Meanwhile, Kansas is flying high after a 35-27 win over Duke that gave the team its first 4-0 start since 2009. The Jayhawks are tied for the seventh-highest scoring average in the country at 46.0 points per game thanks to the efforts of quarterback Jalon Daniels, running back Devin Neal and running back Daniel Hishaw Jr.

Iowa State vs Kansas Odds & Spread

All NCAAF betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IAST: (-146) | KU: (+122)
Spread: IAST: -3 (-110) | KU: +3 (-110)
Total: 57.5 — Over: (-110) | Under: (-110)

Iowa State enters this contest as a small road favorite on the moneyline and the spread. This 3:30 p.m. ET clash also features a total of 57.5 points, which is slightly above average compared to this week's college football projected totals.

Iowa State vs Kansas Prediction & Pick

It's easy to look at the trends and expect a blowout in favor of the Cyclones here. After all, Iowa State is 7-0 in its last seven games against Kansas. This Jayhawks team is different, though. They are converting on 64.9% of their third downs (No. 3 in FBS) and picking up 7.2 yards per play (T-No. 8 in FBS).

The Cyclones are going to have to prepare to defend Daniels both through the air and on the ground, which is something they haven't had to do against a QB so far this season. This Kansas squad has all the momentum in the world right now and with passionate crowd support, it will emerge victorious.

Final Score Prediction: Kansas: 30 | Iowa State: 27

Iowa State vs Kansas Betting Trends

- Iowa State is 7-0 straight up in its last seven games against Kansas.
- The total has hit the over in seven of Iowa state's last 10 games against a Big 12 opponent.
- Kansas is 4-1 against the spread (ATS) in its last five games.
- The total has hit the under in eight of Kansas' last 12 games against Iowa State.

Iowa State vs Kansas Best Bet

All NCAAF betting lines, odds and prop bets are available on FanDuel Sportsbook.

Bettors afraid to take the moneyline here can feel comfortable backing the Jayhawks to keep this game within three points. That spread creates the opportunity to break even if Iowa State wins with a late field goal and also provides an opportunity to win if the game is decided in multiple overtimes.

Kansas is 7-0 against the spread (ATS) in its last seven games overall, while Iowa State is 2-4 ATS in its last six away games. A combination of home-field advantage and momentum is the key to any good college football upset, and the Jayhawks have both of those working in their favor on Saturday.

Bet: Kansas +3 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.