Holly Holm vs Yana Santos Prediction, Odds & Best Bet for UFC on ESPN 43 (Holm's Experience Gets Her Back on Track)

Holly Holm vs. Yana Santos betting preview for UFC on ESPN 43, including predictions, odds and best bets.
Holly Holm vs. Yana Santos betting preview for UFC on ESPN 43, including predictions, odds and best bets. / AP Photo/John Locher

Holm vs Santos Fight Info, Date & Time

UFC on ESPN 43 — Co-Main Event Women's Bantamweight Bout
Holly Holm (14-6, 8 KOs) vs. Yana Santos (14-6, 7 KOs)
Date: Saturday, March 25, 2023
Fight Time: This will be on the main card, which begins at 7 p.m. ET.
Venue: AT&T Center — San Antonio, Texas
Coverage: ESPN+, ESPN

Holm vs Santos Odds & Prop Bets

All UFC on ESPN 43 odds, lines and prop bets are available on FanDuel Sportsbook.
- Holly Holm: (-220)
- Yana Santos: (+168)

Method of Victory:
- Holm by KO/TKO: (TBD)
- Holm by Points: (TBD)
- Holm by Submission: (TBD)
- Santos by KO/TKO: (TBD)
- Santos by Points: (TBD)
- Santos by Submission: (TBD)

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Holm vs Santos Prediction

This is a matchup between two bantamweight fighters that could use the win. After a two-year hiatus, Holly Holm made her return at UFC Vegas 55 with a split-decision loss to Ketlen Vieira. Meanwhile, Yana Santos was knocked out by Irene Aldana in the first round of their fight at UFC 264.

With veteran experience on her side, I see Holm getting the win here. On top of having the height and reach advantages, she also has better strike defense than Santos. Furthermore, Holm's 78% takedown defense should help her stay on her feet against an opponent who averages 1.53 takedowns with 53% accuracy.

Considering how Santos has been knocked out in three times in her last seven fights, I see her being in trouble this weekend. Holm has eight career KO/TKO wins to her name and has a great opportunity to pick up a ninth.

Winner: Holly Holm

Holm vs Santos Best Bet

The moneyline is the only betting option at the moment, making a Holm outright win at -220 odds the best bet for now. Make sure to check back on FanDuel Sportsbook leading up to UFC on ESPN 43 for more playable options.

Bet: Holly Holm ML (-220)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.