Guardians vs Mariners Prediction, Odds & Best Bet for Opening Day (Expect Pitching Duel at T-Mobile Park)

Guardians vs Mariners Game Info

• Date: Thursday, March 30, 2023
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: MLB TV

Opening Day of the 2023 MLB season is finally here. Thursday, March 30's schedule features several exciting matchups, including an American League clash between the Cleveland Guardians and Seattle Mariners.

The 2022 season series between these clubs was lopsided, to say the least. The Mariners won six of their seven meetings with the Mariners last year with the only loss coming by just one run. Needless to say, Seattle looks to continue that trend, whereas Cleveland hopes that a fresh slate leads to better results.

Can the Guardians pull off an upset at T-Mobile Park? Or will the Mariners keep getting the better of Cleveland?

Guardians vs Mariners Odds & Spread

• All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
• Moneyline: CLE: (+104) | SEA: (-122)
• Spread: CLE: +1.5 (-235) | SEA: -1.5 (+190)
• Total: 6.5 -- Over: (-110) | Under: (-110)

The Mariners enter this contest as home favorites on the moneyline and spread per FanDuel Sportsbook's odds. This 10:10 p.m. ET clash also features an over/under of 6.5 runs with both sides available at -110 odds.

Guardians vs Mariners Betting Trends

• Cleveland is 10-2 straight up in its last 12 road games.
• Seattle is 7-3 straight up in its last 10 home games.
• The total has hit the under in five of Cleveland's last seven games.
• The total has hit the under in five of Seattle's last seven games against Cleveland.

Guardians vs Mariners Prediction & Pick

Fans can expect an intense pitching duel tonight. On one side, Shane Bieber takes the mound for the Guardians. The former Cy Young winner was terrific in 2022, going 13-8 with a 2.88 ERA and a 1.04 WHIP while allowing a career-low 1.6 walks per nine innings in 31 starts.

Meanwhile, the Mariners are sending in Luis Castillo to get the job done. The two-time All-Star pitcher split last season between the Cincinnati Reds and Mariners, tallying an 8-6 record with a career-best 2.99 ERA.

Keeping that in mind, I see the Mariners emerging victorious tonight. The Guardians have struggled lately in Seattle, losing six of their last seven trips to T-Mobile Park while being outscored 30-15 along the way.

It'll be a close game due to two talented starting pitchers, but the home crowd and last season's dominance give the Mariners an edge.

Final Score Prediction: Mariners: 3 | Guardians: 2

Guardians vs Mariners Best Bet

I don't see tonight's 6.5-run total being surpassed. Bieber and Castillo's pitching abilities should lead to little offense from both sides. Furthermore, the under was 5-2 in the seven Guardians-Mariners tilts last season with an average of just 5.7 runs scored.

In what should be a solid pitching duel, back the under as the best bet.

Bet: Under 6.5 Runs (-110)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.