Giants vs. Yankees Prediction, Odds & Best Bet for Opening Day (New York Prevails in Pitching Duel)

Giants vs. Yankees Game Info

• Date: Thursday, March 30, 2023
• Time: 1:05 p.m. ET
• Venue: Yankee Stadium -- Bronx, New York
• Coverage: NBC Sports and YES

The 2023 MLB season kicks off with an Opening Day matchup between the New York Yankees and San Francisco Giants at Yankee Stadium. This game will be a homecoming of sorts for the Giants, who played in New York through 1957 before relocating to San Francisco.

Both teams will send their aces to the mound with Logan Webb taking the hill for the Giants and Gerrit Cole getting the call for the Yankees. Runs figure to be at a premium in this game, so which team will come out on top?

Giants vs. Yankees Odds & Spread

• All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
• Moneyline: SF: (+144) | NYY: (-172)
• Spread: SF: +1.5 (-152) | NYY: -1.5 (+126)
• Total: 7 -- Over: (-115) | Under: (-105)

The Yankees enter this interleague matchup as home favorites on the spread and moneyline at FanDuel Sportsbook. This game also has a projected total of 7 runs, which is on the lower side for Thursday's games.

Giants vs. Yankees Betting Trends

• The Yankees are 56-24 in their last 80 home games.
• The Giants are 9-3 in their last 12 road games.
• The Giants are 2-5 in their last seven games at Yankee Stadium.
• The Under is 9-0 in the last nine games played in New York between these two teams.

Giants vs. Yankees Prediction & Pick

After ranking second in the American League with 99 wins last year, the Yankees are expected to be one of the best teams in baseball this year. They open the season with the fourth-best World Series odds on FanDuel Sportsbook and their projected win total is set at 93.5 wins.

The Giants, on the other hand, are forecast for another year of mediocrity. Their offseason was largely viewed as a disappointment coming off an 81-81 campaign, and they aren't expected to be much better in 2023.

New York also has a clear home-field advantage at Yankee Stadium, where the Yanks were 57-24 last year. San Francisco was mediocre on the road, going 37-44 away from home.

While Webb is an outstanding pitcher in his own right, Cole is a perennial Cy Young contender and one of the best in the sport. New York also has a superior offense after ranking second in MLB in runs per game last year and still has reigning AL MVP Aaron Judge in the heart of its lineup.

Webb will do his best to keep the game close, but all signs point to the Yankees taking this one.

Final Score Prediction: Yankees: 4 | Giants: 2

Giants vs. Yankees Best Bet

With New York at home and Gerrit Cole on the bump, we love getting the Yankees' run line at plus odds. The Giants have really struggled against the Bronx Bombers lately, going 2-5 in their last seven trips to Yankee Stadium and losing their last four games to New York overall. San Francisco will struggle to score against Cole and the Pinstripes' bats will break out eventually, helping the Yankees win by multiple runs.

Bet: New York Yankees -1.5 (+126)

Game odds refresh periodically and are subject to change.