Giants vs Twins Prediction, Odds & Best Bet for May 22 (Bailey Ober Gives Minnesota Pitching Advantage)

San Francisco Giants vs Minnesota Twins prediction, odds and betting insights for MLB regular season game.
San Francisco Giants vs Minnesota Twins prediction, odds and betting insights for MLB regular season game. / AP Photos/Abbie Parr

The Minnesota Twins (25-22) will aim to stay atop the American League Central when they host the San Francisco Giants (22-24) in the first matchup of their three-game series on Monday, May 22.

Giants vs Twins Game Info

  • Date: Monday, May 22, 2023
  • Time: 7:40 p.m. ET
  • Venue: Target Field -- Minneapolis, MN
  • Coverage: FS1, NBCSBA and BSN

These teams have only met head-to-head in a regular season series once over the last five years as the Twins secured a three-game home sweep in 2022. Both teams enter Monday with momentum as San Francisco has won five of its last six contests and Minnesota has won six of its last 11 contests.

Giants vs Twins Odds & Spread

  • All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
  • Moneyline: SF: (+128) | MIN: (-152)
  • Spread: SF: +1.5 (-154) | MIN: -1.5 (+128)
  • Total: 9 -- Over: (-102) | Under: (-120)

The Twins enter this contest as home favorites on the moneyline and spread per FanDuel Sportsbook's odds. This 7:40 p.m. ET clash also features an over/under of 9 runs with the under favored at -120 odds.

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Giants vs Twins Betting Trends

  • San Francisco is 4-10 straight up in its last 14 away games.
  • The total has hit the over in four of San Francisco's last five away games against Minnesota.
  • Minnesota is 6-3 straight up in its last nine games against an NL West opponent.
  • The total has hit the over in six of Minnesota's last nine games.

Giants vs Twins Prediction & Pick

The Giants are starting John Brebbia on Monday, who owns a 4.26 ERA and 1.16 WHIP across 19.0 innings. He has yet to record more than five outs in any of his appearances, so the expectation is that someone like Sean Manaea (7.81 ERA) or Tristan Beck (5.71 ERA) will see multiple innings of action.

On the other side, the Twins will send Bailey Ober to the mound. The 27-year-old has enjoyed an impressive start to the season as he has posted a 1.78 ERA to go along with a 0.96 WHIP in five starts (3-0 record). The Minnesota hurler has logged at least 6 strikeouts in each of his last four outings, too.

Not only do the Twins have an advantage on the mound in this one, but they also have an advantage at the plate. Minnesota averages 5.18 runs per home game versus 4.20 runs per away game. That is dangerous considering San Francisco allows 5.25 runs per away game on the year (No. 25 in MLB).

Final Score Prediction: Giants: 3 | Twins: 6

Giants vs Twins Best Bet

As mentioned above, Ober has been tallying strikeouts with ease. He has posted at least 6 strikeouts in each of his last four starts despite facing talented lineups such as the Dodgers and the Padres. Ober now gets to face a San Francisco lineup that averages the third-most strikeouts per game in the majors (9.63) and ranks 22nd in terms of swinging strike percentage (11.8%). Trust Ober on Monday.

Bet: Bailey Ober Over 5.5 Strikeouts (-112)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.