Giants vs Titans Prediction, Odds & Betting Trends for NFL Week 1 Game on FanDuel Sportsbook (Sept 11)

Giants vs Titans Week 1 Game Info

2022 NFL Regular Season Game
New York Giants (0-0, 0-0 Away) vs. Tennessee Titans (0-0, 0-0 Home)
Date: Sunday, Sept. 11, 2022
Time: 4:25 p.m. ET
Venue: Nissan Stadium — Nashville, TN
Coverage: FOX

Week 1 of the 2022 NFL season includes a showdown between the New York Giants and Tennessee Titans. The Giants hope to see big things in Brian Daboll's first season as the head coach, however, there are still doubts about the returning playing cast, especially quarterback Daniel Jones, since joining the league.

The Titans might not look as intimidating without A.J. Brown, but they're still back-to-back AFC South champs for a reason. Derrick Henry is still one of the top three running backs in the league and with the help of a solid defense, Tennessee is still a tough team to beat.

Giants vs Titans Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: NYG: (+198) | TEN: (-240)
Spread: NYG: +5.5 (-110) | TEN: -5.5 (-110)
Total: 43.5 — Over: (-114) | Under: (-106)

Updated (Sunday, Sept. 11, 11:15 a.m. EST): Updated odds were provided from FanDuel Sportsbook. The point spread remains steady at 5.5 points in favor of the Titans.

The Titans enter this contest as the favorite on the moneyline and the spread. This 4:25 p.m. ET clash also features a total of 43.5, which is a bit low compared to this week's NFL projected totals.

Giants vs Titans Prediction & Pick

With a new head coach, there's a sense of optimism surrounding the Giants. Having said that, Jones is a serial underperformer and there's also the question about whether or not New York's wideouts can stay healthy this year. Needless to say, there's a lot left for the Giants to prove.

The Titans love to run the ball and, fortunately, the Giants gave up 129.0 rushing yards per game last year (No. 25). Henry is ready to pick up from where he left off before his 2021 regular season-ending injury and I don't think that New York is ready to handle that just yet. I expect the Titans to get out to a lead early on and not look back.

Final Score Prediction: Titans: 28 | Giants: 13

Giants vs Titans Betting Trends

- The Giants are 0-6 against the spread (ATS) in their last six games.
- Tennessee is 6-1 ATS in its last seven games against the Giants.
- The total has hit the under in eight of the Giants' last eight games against AFC teams.
- The total has hit the under in each of Tennessee's last five home games.

Giants vs Titans Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

With the Titans being the clear-cut better team here, I like their odds to cover the 5.5-point spread. Once Tennessee gets the lead, it's going to be tough for the Giants to close that gap, especially with Henry running out the clock. Considering that the Titans also perform well ATS when the Giants are involved, the spread is the best option here.

Bet: Titans -5.5 (-112)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.