Eagles vs Colts Prediction, Odds & Best Bet for Week 11 (Sirianni Victorious in Return to Lucas Oil Stadium)

Eagles vs Colts Week 11 Game Info

2022 NFL Regular Season Game
Philadelphia Eagles (8-1, 4-0 Away) vs. Indianapolis Colts (4-5-1, 2-2 Home)
Date: Sunday, Nov. 20, 2022
Time: 1 p.m. ET
Venue: Lucas Oil Stadium — Indianapolis, IN
Coverage: CBS

Week 11 of the 2022 NFL season includes a showdown between the Philadelphia Eagles and Indianapolis Colts. The Eagles are searching for a way to rebound after suffering their first defeat in a 32-21 loss to the Washington Commanders.

Meanwhile, the Colts are trending in the opposite direction following a 25-20 victory against the Las Vegas Raiders. Star running back Jonathan Taylor had a massive performance in Jeff Saturday's first game behind the bench, rushing for 147 yards and a touchdown on 22 carries.

Eagles vs Colts Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PHI: (-290) | IND: (+235)
Spread: PHI: -6.5 (-112) | IND: +6.5 (-108)
Total: 45.5 —Over: (-106) | Under: (-114)

Updated (Sunday, Nov. 20, 12:20 p.m. ET): The line on this game remains relatively unchanged. The over/under opened up at 44.5 points, but has increased to 45.5 points. Philadelphia's moneyline odds fell from -295 to -290.

The Eagles enter this contest as clear favorites on the moneyline and spread on FanDuel Sportsbook's updated odds. This inter-conference clash also features an over/under of 44.5, which is averaged compared to the Week 11 totals. 

Eagles vs Colts Prediction & Pick

The Eagles clearly underestimated the Commanders last week and ended up paying for it. Don't count on that happening again as Philadelphia head coach Nick Sirianni has a chance to beat the Colts, a team that he was the offensive coordinator for from 2018 to 2020.

While the Colts looked rejuvenated under Saturday's debut last week, there's still a lot to prove. Indianapolis has only won back-to-back games once this season and has only scored more than 16 points once in the last four games.

With Matt Ryan also needing to prove that he can string together consecutive strong showings, I'm going with the Eagles bouncing back on the road.

Final Score Prediction: Eagles: 26 | Colts: 20

Eagles vs Colts Betting Trends

- Philadelphia is 6-1 straight up in its last seven road games.
- Indianapolis is 6-1 against the spread (ATS) in its last seven games against Philadelphia.
- The total has hit the over in five of Philadelphia's last six games.
- The total has hit the over in six of Indianapolis' last seven games against Philadelphia.

Eagles vs Colts Best Bet

When it comes to best bets, I'm taking the over on the 44.5-point total. Not only has the over been reached in five of Philadelphia's last six games this season, but it's also done so in six of the last seven Eagles-Colts matchups.

The Eagles also own the third-best offense in the NFL while the Colts' playmakers seem to be livelier Saturday behind the bench. In an important game for both sides, go with the over here.

Bet: Over 44.5 Points (-114)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.