NFL - Odds & Predictions

Eagles vs Cardinals Prediction, Odds & Betting Trends for NFL Week 5 Game on FanDuel Sportsbook (Oct 9)

Larry Rupp
Philadelphia Eagles vs Arizona Cardinals prediction, odds and betting trends for NFL Week 5 game.
Philadelphia Eagles vs Arizona Cardinals prediction, odds and betting trends for NFL Week 5 game. / AP Photos/Matt Slocum
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Eagles vs Cardinals Week 5 Game Info

2022 NFL Regular Season — Week 5
Philadelphia Eagles (4-0, 2-0 Away) vs. Arizona Cardinals (2-2, 0-2 Home)
Date: Sunday, October 9, 2022
Time: 4:25 p.m. ET
Venue: State Farm Stadium — Glendale, AZ
Coverage: FOX

The Philadelphia Eagles will look to start a NFL season 5-0 for the first time since 2004 when they visit the Arizona Cardinals in Week 5. The Eagles beat the Jacksonville Jaguars on Sunday by a score of 29-21 thanks to Miles Sanders' big day. He logged 156 yards and 2 touchdowns on 29 touches.

Meanwhile, the Cardinals overcame yet another slow start in a solid 26-16 victory over the Carolina Panthers. Arizona remains the only squad in the league that has yet to score a single point in the first quarter this season. It's a facet of the team's game that obviously needs to improve moving forward.

Eagles vs Cardinals Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: PHI: (-225) | ARI: (+188)
Spread: PHI: -5.5 (-106) | ARI: +5.5 (-114)
Total: 48.5 — Over: (-115) | Under: (-105)

Updated (Sunday, Oct. 9, 10:00 a.m. EST): The Eagles enter this contest as a clear road favorite on the moneyline and the spread on FanDuel Sportsbook's updated odds, which haven't moved much this week. This 4:25 p.m. ET clash also features the second-highest projected total (48.5) on the NFL Week 5 slate.

Eagles vs Cardinals Prediction & Pick

This is the first true opportunity for the Eagles to prove they are one of the best teams in the NFC. So far, their first four games have come against opponents that did not make the playoffs last season. That is no longer the case. Kyler Murray is the first dual-threat quarterback they will take on as well.

There's no reason to stop backing Philly now, though. The Eagles are averaging the second-most yards per game (435.5) and allowing the third-fewest yards per game (277.3) in the NFL. They have put together an elite balanced roster and will cause head coach Kliff Kingsbury a ton of frustration.

Final Score Prediction: Eagles: 24 | Cardinals: 20

Eagles vs Cardinals Betting Trends

- Philadelphia is 4-1 straight up in its last five away games.
- The total has hit the under in five of Philadelphia's last seven games against Arizona.
- Arizona is 0-7 against the spread (ATS) in its last seven home games.
- The total has hit the under in six of Arizona's last nine games.

Eagles vs Cardinals Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

The Eagles have the inside track for a victory here, but they have historically struggled in State Farm Stadium. That makes avoiding the spread and focusing on the point total the best option here. After all, the under has hit in five of the last seven head-to-head matchups between Philly and Arizona.

The under has also hit in six of the Cardinals' last nine games overall and in five of the Eagles' last seven games against a NFC West opponent. Yes, these two offenses are filled with talented stars. However, these defenses are, too. A sluggish start all around will lead to less points than expected.

Bet: Under 48.5 Points (-105)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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