Dolphins vs Bills Prediction, Odds & Best Bets for Week 15 (Buffalo Gets Revenge on Divisional Rival)

Dolphins vs Bills Week 15 Game Info

2022 NFL Regular Season — Week 15
Miami Dolphins (8-5, 3-4 Away) vs. Buffalo Bills (10-3, 5-1 Home)
Date: Sunday, Dec. 17, 2022
Time: 8:15 p.m. ET
Venue: Highmark Stadium — Orchard Park, NY
Coverage: NFL Network

AFC East rivals fighting for playoff positioning meet head-to-head in Week 15 as the Miami Dolphins visit the Buffalo Bills. Miami is coming off a disappointing 23-17 loss to the Los Angeles Chargers on Sunday. Quarterback Tua Tagovailoa completed 10 of his 18 passes for 145 yards and 1 touchdown.

Meanwhile, the Bills took care of business in a gritty 20-12 win over the New York Jets in Week 14. It was a stout defensive effort as Gregory Rousseau logged 2.0 sacks and Matt Milano tallied 7 tackles. Quarterback Josh Allen paced the offense with 147 passing yards, 47 rushing yards and 2 scores.

Dolphins vs Bills Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: MIA: (+290) | BUF: (-360)
Spread: MIA: +7.5 (-115) | BUF: -7.5 (-105)
Total: 42.5 — Over: (-106) | Under: (-114)

The Bills enter this contest as clear home favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Saturday night clash also features one of the lower totals on the Week 15 slate at 42.5 points.

Dolphins vs Bills Prediction & Pick

Miami made an early season statement by beating Buffalo, 21-19, in Week 3. It's important to note that game was played at Hard Rock Stadium in perfect sunny weather, though. Saturday night's game will be played at Highmark Stadium, where freezing temperatures and snow flurries are expected.

That's a valuable home-field advantage for a Bills team that knows how to get the job done in the cold. Buffalo allows only 14.4 points per game (No. 2 in NFL) and a red zone scoring percentage of 30.8% (No. 2 in NFL) when at home this year. It has also logged 13 takeaways across six home games.

The Bills had won seven straight games against the Dolphins prior to Week 2 and I anticipate them exacting some revenge.

Final Score Prediction: Dolphins: 17 | Bills: 27

Dolphins vs Bills Betting Trends

- Miami is 1-5 against the spread (ATS) in its last six away games.
- The total has hit the over in four of Miami's last six games.
- Buffalo is 7-1 straight up in its last eight games against Miami.
- The total has hit the under in nine of Buffalo's last 11 games.

Dolphins vs Bills Best Bet

The play of Tagovailoa will obviously make a huge impact in this game. He is coming off one of his worst performances of the season and now has to face a Bills team that has posted the seventh-best pass defense DVOA rating in the NFL. Buffalo allows only 9.5 yards per completion (T-No. 7 in NFL).

The Alabama product could be in for a long day, especially since the Bills don't leave any room for error. They average 31.2 points per home game (No. 2 in NFL). Buffalo is 7-3 against the spread (ATS) in its last 10 games in December, while Miami is 1-5 ATS in its last six away games. Back the Bills.

Bet: Buffalo Bills -7.5 (-105)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.