Dolphins vs 49ers Prediction, Odds & Best Bets for Week 13 (Miami's Offense Shines in Road Upset)

Larry Rupp
Miami Dolphins vs San Francisco 49ers prediction, odds and best bets for NFL Week 13 game.
Miami Dolphins vs San Francisco 49ers prediction, odds and best bets for NFL Week 13 game. / AP Photos/Paul Sancya
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Dolphins vs 49ers Week 13 Game Info

2022 NFL Regular Season — Week 13
Miami Dolphins (8-3, 3-2 Away) vs. San Francisco 49ers (7-4, 4-1 Home)
Date: Sunday, Dec. 4, 2022
Time: 4:05 p.m. ET
Venue: Levi's Stadium — Santa Clara, CA
Coverage: FOX

Two teams vying for better playoff positioning meet head-to-head in Week 13 as the Miami Dolphins visit the San Francisco 49ers. The Dolphins are coming off a dominant 30-15 win over the Houston Texans on Sunday. Cornerback Xavien Howard took back a recovered fumble 16 yards for a score.

Meanwhile, the 49ers leaned on its defense to defeat the New Orleans by a score of 13-0 in Week 12. San Francisco made crucial red zone stops on back-to-back possessions in the fourth quarter to seal the victory. Defensive end Nick Bosa's late sack of QB Andy Dalton upped his season total to 11.5.

Dolphins vs 49ers Odds & Spread

Updated (Sunday, Dec. 4, 12:05 p.m. ET)

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: MIA: (+184) | SF: (-220)
Spread: MIA: +4.5 (-110) | SF: -4.5 (-110)
Total: 45.5 — Over: (-110) | Under: (-110)

The 49ers enter this contest as small home favorites on the moneyline and the spread on FanDuel Sportsbook's updated odds. This 4:05 p.m. ET clash also features one of the higher totals on the Week 13 slate at 46.5 points.

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Dolphins vs 49ers Prediction & Pick

The 30-15 final score was a bit misleading for Miami as they scored all of those points in the first half. The offense was humming both on the ground as well as through the air and could've racked up 50 points by the time the final whistle blew. The starters rested for most of the second half, though.

The key for Miami is quarterback Tua Tagovailoa given it is undefeated when he plays a majority of the offensive snaps. The third-year pro has thrown 19 touchdowns compared to 3 interceptions and now gets to face a San Francisco defense that allows 236.2 passing yards per home game (No. 22 in NFL).

Miami is also 4-1 straight up in its last five games against San Francisco, so I'll back the road team.

Final Score Prediction: Dolphins: 27 | 49ers: 24

Dolphins vs 49ers Betting Trends

- Miami is 5-0 against the spread (ATS) in its last five Week 13 games.
- The total has hit the over in four of Miami's last five away games.
- San Francisco is 8-1 straight up in its last nine home games.
- The total has hit the over in four in San Francisco's last five games against Miami.

Dolphins vs 49ers Best Bet

There's a lot to like about the Dolphins' chances of keeping those one close on Sunday. The 49ers defense ranks as one of the best in the NFL, but it was torched for 44 points the last time it faced a top-10 offense (Chiefs). Keeping up with both Tyreek Hill and Jaylen Waddle is as difficult as it gets.

It's worth pointing out that Miami is 5-0 against the spread (ATS) in its last five Week 13 games and 7-2 ATS in its last nine games played in December. This is the time of the season in which the Dolphins tend to find their groove. On the other side, San Francisco is 2-4 ATS in its last six Week 13 games.

Bet: Miami Dolphins +3.5 (-104)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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