DePaul vs Creighton Prediction, Odds & Best Bet for Dec. 25 (Bluejays Continue Dominance Over Blue Demons)

Devon Platana
DePaul vs Creighton prediction, odds and betting insights for NCAA college basketball regular season game.
DePaul vs Creighton prediction, odds and betting insights for NCAA college basketball regular season game. / AP Photos/Eric Gay
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DePaul vs Creighton Game Info

2022-23 NCAA College Basketball Regular Season Game
DePaul Blue Demons (6-6, 0-1 Big East) vs. Creighton Bluejays (7-6, 1-1 Big East)
Date: Sunday, Dec. 25, 2022
Time: 4:30 p.m. ET
Venue: CHI Health Center Omaha — Omaha, NE
Coverage: FOX

There are a few NCAA college basketball games slated for Christmas Day, including a Big East battle between the DePaul Blue Demons and Creighton Blue Jays.

DePaul enters tonight's game having lost back-to-back outings — mostly recently an 83-45 blowout loss to Northwestern last weekend. Meanwhile, Creighton ended its six-game losing streak on Thursday with a 78-56 win against Butler, highlighted by a game-high 19 points from Ryan Kalkbrenner.

Can DePaul prevent its losing skid from lengthening with a win tonight? Or will Creighton prove that its latest victory wasn't a fluke and that more positive results are on the way?

DePaul vs Creighton Odds & Spread

All NCAA college basketball betting lines, odds and prop bets.
Moneyline: DEP: (+920) | CREI: (-1800)
Spread: DEP: +15.5 (-110) | CREI: -15.5 (-110)
Total: 146.5 - Over: (-110) | Under: (-110)

Creighton enters this contest as the clear favorite on the moneyline and spread per FanDuel Sportsbook's odds. This 4:30 p.m. ET clash also features an over/under of 146.5 points with -110 odds on both the over and under. 

DePaul vs Creighton Prediction

Creighton hasn't been playing the best basketball lately, but that could change tonight. The Bluejays always turn things up when facing the Blue Demons, winning 21 of the last 22 battles between the Big East rivals. On top of that, Creighton has won 16 straight games against DePaul, having not lost since January 2015.

DePaul also just isn't good on the road, averaging 73.0 points against while only scoring 64.7. Meanwhile, Creighton is holding opponents to 59.3 PPG at CHI Health Center Omaha while boasting a plus-19.5 scoring margin at home. Considering how the Blue Demons are a minus-8.3 on the road, I don't expect them to stand much of a chance.

Look for Creight to defeat DePaul with relative ease yet again.

Final Score Prediction: Creighton: 78 | DePaul: 63

DePaul vs Creighton Betting Trends

- DePaul is 0-7 against the spread (ATS) in its last seven road games against Creighton.
- Creighton is 1-5 straight up in its last six games played in December.
- The total has hit the under in seven of DePaul's last eight games.
- The total has hit the under in four of Creighton's last five games against DePaul.

DePaul vs Creighton Best Bet

Creighton has absolutely blown out DePaul more often than not, winning each of the last 16 meetings by an average of 15.5 points. Having said that, only six of those victories have come by 16 or more points.

While I do think that the Bluejays will win big, their being 1-4 ATS in their last five games makes them hard to trust. On the other hand, the Blue Demons are at least 4-4 ATS in their last eight and have covered the spread in five of their last seven meetings against fellow Big East schools.

Erring on the side of caution, I'll take DePaul covering this time around.

Bet: DePaul +15.5 (-110)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.

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