Colts vs Titans Prediction, Odds & Betting Trends for NFL Week 7 Game on FanDuel Sportsbook (Oct 23)

Colts vs Titans Week 7 Game Info

2022 NFL Regular Season — Week 7
Indianapolis Colts (3-2-1, 1-1-1 Away) vs. Tennessee Titans (3-2, 1-1 Home)
Date: Sunday, October 23, 2022
Time: 1:00 p.m. ET
Venue: Nissan Stadium — Nashville, TN
Coverage: CBS

A pair of AFC South rivals meet head-to-head in Week 7 NFL action as the Indianapolis Colts visit the Tennessee Titans. The Colts have now earned back-to-back wins following their 34-27 victory over the Jacksonville Jaguars. Quarterback Matt Ryan shined with 389 passing yards and 3 touchdowns.

Meanwhile, the Titans ripped off three straight victories after an 0-2 start to the season before going through their bye week. Running back Derrick Henry had his best performance of the season in a Week 5 win over the Washington Commanders with 102 yards and 2 touchdowns on 28 carries.

Colts vs Titans Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+120) | TEN: (-142)
Spread: IND: +2.5 (-108) | TEN: -2.5 (-112)
Total: 42.5 — Over: (-115) | Under: (-105)

Updated (Sunday, Oct. 23, 12:00 p.m. EST): This line remains virtually unchanged. Indianapolis' moneyline odds impvoed slightly to +120 (from +126) but the spread and over/under holds steady.

The Titans enter this contest as a small home favorite on the moneyline and the spread. This 1:00 p.m. ET clash also features one of the lower totals on the Week 7 slate at 42.5 points.

Colts vs Titans Prediction & Pick

This game represents the fifth divisional matchup in the first seven weeks of the season for the Colts. That includes a 24-17 home loss to this same Titans team back in Week 4. Tennessee racked up 3.0 sacks, 1 interception and 1 fumble recovery in a game that Ryan struggled to play clean football in.

This one is going to come down to Ryan, too. Running back Jonathan Taylor remains banged up and the Titans have posted the third-best rush defense DVOA rating in the NFL. Tennessee has won five of its last six games against Indianapolis and I don't expect that dominance to stop on Sunday.

Final Score Prediction: Colts: 17 | Titans: 21

Colts vs Titans Betting Trends

- Indianapolis is 1-5 straight up in its last six games against Tennessee.
- The total has hit the under in 10 of Indianapolis' last 11 games.
- Tennessee is 6-0 against the spread (ATS) in its last six games in October.
- The total has hit the over in four of Tennessee' last six games against Indianapolis.

Colts vs Titans Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

This is a divisional matchup that has been controlled by the Titans as of late. Not only is Tennessee 5-1 straight up in its last six games against Indianapolis, but it is also 5-1 against the spread (ATS) in that same span. The Colts are a dismal 1-4 ATS in their last five games against AFC South opponents.

The Titans can drain the clock with Henry assuming they can get out to an early lead. That's a fair assumption to make considering Tennessee averages a league-high 8.4 first quarter points per game. Indianapolis averages only 1.7 first quarter points per game (No. 31 in NFL). The Titans roll.

Bet: Tennessee Titans -2.5 (-120)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.