NFL - Odds & Predictions

Colts vs Raiders Prediction, Odds & Best Bets for Week 10 (Las Vegas Earns a Much-Needed Home Victory)

Larry Rupp
Indianapolis Colts vs Las Vegas Raiders prediction, odds and best bets for NFL Week 10 game.
Indianapolis Colts vs Las Vegas Raiders prediction, odds and best bets for NFL Week 10 game. / AP Photos/Gary McCullough
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Colts vs Raiders Week 10 Game Info

2022 NFL Regular Season — Week 10
Indianapolis Colts (3-5-1, 1-3-1 Away) vs. Las Vegas Raiders (2-6, 2-1 Home)
Date: Sunday, Nov. 13, 2022
Time: 4:05 p.m. ET
Venue: Allegiant Stadium — Las Vegas, NV
Coverage: CBS

Two teams looking to get back on track meet head-to-head in Week 10 as the Indianapolis Colts visit the Las Vegas Raiders. The Colts fell short against the New England Patriots in a 26-3 Week 9 loss. Quarterback Sam Ehlinger completed 15 of his 29 pass attempts for 103 yards and 1 interception.

Meanwhile, Las Vegas blew a 17-point lead against the Jacksonville Jaguars and lost by a score of 27-20 on Sunday. Wide receiver Davante Adams' best performance as a Raider was wasted. The three-time Pro Bowler dominated by hauling in 10 of his 17 targets for 146 yards and 2 touchdowns.

Colts vs Raiders Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+194) | LV: (-235)
Spread: IND: +5.5 (-105) | LV: -5.5 (-115)
Total: 42.5 — Over: (-110) | Under: (-110)

The Raiders enter this contest as a notable home favorite on the moneyline and the spread. This 4:05 p.m. ET clash also features one of the lower totals on the Week 10 slate at 42.5 points.

Colts vs Raiders Prediction & Pick

There's no denying that the Indianapolis Colts are a mess right now. The team has scored less than 17 points in each of its last three games and head coach Frank Reich was fired on Tuesday. Ehlinger has also only logged 304 yards to go along with 0 touchdowns and 1 interception across two starts.

This is a bounce-back spot for the Raiders. As much as Las Vegas has struggled to perform on the road, it is averaging a reliable 31.0 points per game at home this season (T-No. 3 in NFL). Quarterback Derek Carr has thrown for 681 yards and 3 touchdowns (0 interceptions) in three home contests, too.

Final Score Prediction: Colts: 14 | Raiders: 24

Colts vs Raiders Betting Trends

- Indianapolis is 6-3 straight up in its last nine games against Las Vegas.
- The total has hit the under in 13 of Indianapolis' last 14 games.
- Las Vegas is 4-1 against the spread (ATS) in its last five home games.
- The total has hit the over in four of Las Vegas' last five games against Indianapolis.

Colts vs Raiders Best Bet

Head coach Josh McDaniels couldn't have asked for a better matchup to right the ship in Las Vegas. The Raiders are 9-4 against the spread (ATS) in their last 13 games against the Colts and 4-1 ATS in their last five home games. With Carr and Adams finally clicking, this one could be over by halftime.

Not only does the Raiders' offense have a chance to shine here, but so does the defense. Ehlinger was sacked nine times last week and the Colts have allowed a whopping 35 sacks this year. That's the worst mark in the NFL and gives players like Maxx Crosby and Chandler Jones a shot to wreak havoc.

Bet: Las Vegas Raiders -5.5 (-115)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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