Colts vs Jaguars Expert Picks & Predictions for Week 2 NFL Game

Fans are settling in after an exciting first week of NFL action and buckling up for another promising set of matchups in Week 2. A pair of AFC South rivals meet head-to-head as the Indianapolis Colts visit the Jacksonville Jaguars. Both teams are looking for their first victory of the 2022 season.

The Colts will be looking to bounce back after playing to a disappointing tie against the Houston Texans in Week 1. Meanwhile, the Jaguars will be aiming to give the home crowd something to cheer about for the first time in a while, especially with Trevor Lawrence in desperate need of a good game.

Should Indianapolis really be favored by more than a field goal at TIAA Bank Field? Does Jacksonville have any chance of grabbing an edge in the division with an upset victory? Here's what projection models and experts across the industry have to say about the Colts vs Jaguars Week 2 matchup.

Colts vs Jaguars Projections

ESPN FPI: Colts (54.4%)
numberFire: Colts (70.8%)
FiveThirtyEight: Colts (65%)
Betting Favorite: Colts (-3.5)

Projected Winner: Colts (4)

Colts vs Jaguars Expert Picks

ESPN Experts: Colts (7), Jaguars (3)
Sports Illustrated Experts: Colts (4), Jaguars (1)
CBS Sports Experts: Colts (6), Jaguars (2)

Expert Totals: Colts (17), Jaguars (6)

There's not many people backing head coach Doug Pederson's team in Week 2. Only six of the 23 experts chose Jacksonville here, which lines up with what the betting markets are saying.

The projection models are backing up those picks, too. ESPN was the only one to give the Colts less than a 65% chance of taking down their AFC South rival on Sunday.

Divisional matchups can be tough to predict, so fans shouldn't rule out the possibility of an upset.

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.