Colts vs Broncos Opening Odds, Betting Lines & Prediction for Week 5 Game on FanDuel Sportsbook

Week 4 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 5, giving us an early preview of next week's slate.

Week 5's edition of Thursday Night Football sets up an exciting matchup between the Indianapolis Colts and Denver Broncos.

Colts vs Broncos Odds & Lines Week 5

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (+118) | DEN: (-138)
Spread: IND: +2.5 (-104) | DEN: -2.5 (-118)
Total: N/A — Over: (N/A) | Under: (N/A)

The Broncos are poised for a hard-fought game at home in Week 5 against the Colts. Denver is an early -138 moneyline favorite, but favored by 2.5 points on the spread.

Colts vs Broncos Prediction Week 5

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
Colts: 41.1% to win
Broncos: 58.4% to win

This contest could come down to a few plays in the fourth quarter, according to the opening betting lines. ESPN's FPI backs up that outcome as well. I'm siding with the Broncos here given the home-field advantage they have working in their favor. This is a defense that feeds off the support of the crowd and continues to earn one red zone stop after another. Keep in mind quarterback Matt Ryan has also struggled on the road this season, so give me Russell Wilson's Broncos to cover -2.5 (-118).

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.