Colts vs Bills Prediction, Odds & Betting Trends for NFL Preseason Game on FanDuel Sportsbook (Aug 13)

Indianapolis Colts vs Buffalo Bills prediction, odds and betting trends for NFL preseason game.
Indianapolis Colts vs Buffalo Bills prediction, odds and betting trends for NFL preseason game. / AP Photos/Michael Conroy

Colts vs Bills Preseason Game Info

2022 NFL Preseason Game
Indianapolis Colts (0-0) vs. Buffalo Bills (0-0)
Date: Saturday, August 13, 2022
Time: 4:00 p.m. ET
Venue: Highmark Stadium — Orchard Park, NY
Coverage: NFL Network

The Indianapolis Colts and Buffalo Bills meet head-to-head in preseason action on Saturday night. Colts fans will be getting their first glimpse of offseason trade acquisition Matt Ryan. The veteran quarterback is set to be the team's third different Week 1 starting QB in the last three seasons.

Meanwhile, Bills fans should expect to see a lot of backups Case Keenum and Matt Barkley in action. Starting QB Josh Allen will not suit up for this game. Rookie running back James Cook will be on the field, though. The second-round pick is expected to play an immediate role on offense this fall.

Colts vs Bills Odds & Spread

All NFL preseason betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: IND: (-130) | BUF: (+110)
Spread: IND: -1.5 (-115) | BUF: +1.5 (-105)
Total: 35.5 — Over: (-110) | Under: (-110)

The Colts enter this contest as a slight favorite on the moneyline and the spread. This 4 p.m. ET clash also features the fourth-highest total of Saturday's eight-game preseason slate.

Colts vs Bills Prediction & Pick

The Colts have gone 7-3-1 against the spread in the preseason with Frank Reich as their head coach. If this game is close down the stretch, look for veteran running backs Philip Lindsay and Ty'Son Williams to make the difference. Both ball-carriers average at least 4.5 yards per carry in their career.

There's not a lot to like about Buffalo's Matt Barkley, either. The six-year pro owns a 58.4% career completion percentage and has tossed 11 touchdowns compared to 22 interceptions. Seeing him lead a game-winning drive would be surprising at this point, so back the Colts to grab a road victory.

Final Score Prediction: Colts: 21 | Bills: 17

Colts vs Bills Betting Trends

- Indianapolis is 6-1 against the spread (ATS) in its last seven away games.
- The total has hit the under in each of Indianapolis' last five games.
- Buffalo is 8-4 straight up in its last 12 games against Indianapolis.
- The total has hit the over in five of Buffalo's last seven games.

Colts vs Bills Best Bet

All NFL preseason betting lines, odds and prop bets are available on FanDuel Sportsbook.

The news that Allen won't be playing has likely played a role in this total dropping to the 35.5-point mark. This game still has offensive shootout written all over it. This total has hit the over in five of the Bills' previous seven preseason games as well as two of the Colts' three preseason games in 2021.

Not only that, but this total has hit the over in each of the last four head-to-head preseason matchups between Buffalo and Indianapolis. That includes a 24-16 Bills win in 2019. These are two of the deepest rosters in the NFL, so trust the trends here and back another high-scoring affair to occur.

Bet: Over 35.5 Points (-110)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.