Chiefs vs Chargers Odds & Best Bets for Sunday Night Football (Offenses Reign Supreme in AFC West Showdown)

Chiefs vs Chargers Week 11 Game Info

2022 NFL Regular Season — Week 11
Kansas City Chiefs (7-2, 3-1 Away) vs. Los Angeles Chargers (5-4, 2-2 Home)
Date: Sunday, Nov. 20, 2022
Time: 8:20 p.m. ET
Venue: SoFi Stadium — Inglewood, CA
Coverage: NBC

The Kansas City Chiefs will look to remain atop the AFC standings when they face off against the Los Angeles Chargers in Week 11 NFL action. The Chiefs took care of business in Week 10 with a 27-17 win over the Jacksonville Jaguars. Quarterback Patrick Mahomes paved the way with 4 touchdowns.

Meanwhile, the Chargers fell short against the San Francisco 49ers in a 22-16 loss on Sunday night. The offense struggled to get anything going as quarterback Justin Herbert threw for a season-low 196 yards and running back Austin Ekeler logged just 24 rushing yards. LA needs to bounce back.

Chiefs vs Chargers Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: KC: (-295) | LAC: (+240)
Spread: KC: -6.5 (-112) | LAC: +6.5 (-108)
Total: 50 — Over: (-110) | Under: (-110)

The Chiefs enter this contest as a clear road favorite on the moneyline and the spread. This Sunday night clash also features one of the higher totals on the Week 11 slate at 50 points.

Chiefs vs Chargers Prediction & Pick

The Chargers held a 17-7 lead over the Chiefs early in the third quarter during a Week 2 matchup between these AFC West rivals. That was before Kansas City scored 20 unanswered points and escaped with a 27-24 home win. Head coach Brandon Staley's defense simply fell apart late.

Los Angeles is at their best when Ekeler is bursting through holes. The only problem is that Kansas City has held him to 38.6 rushing yards per game across 10 head-to-head matchups. The Chiefs are 14-3 straight up in their last 17 games against the Chargers and I don't think that dominance will stop.

Final Score Prediction: Chiefs: 30 | Chargers: 24

Chiefs vs Chargers Betting Trends

- Kansas City is 14-3 straight up in its last 17 games against the Chargers.
- The total has hit the over in seven of Kansas City's last eight away games.
- The Chargers are 6-3 against the spread (ATS) in their last nine games.
- The total has hit the over in six of the Chargers' last eight home games.

Chiefs vs Chargers Best Bet

Divisional games tend to always come down to the final few possessions, especially in the AFC West. That makes shifting gears to the point total a safe move here. The total has hit the over in seven of the Chiefs' last eight away games as well as in six of the Chargers' last eight games at SoFi Stadium.

Keep in mind each of the last four meetings between Kansas City and Los Angeles have resulted in more than 50 points being scored. That's what happens when Mahomes, Herbert, Ekeler and Travis Kelce are all on the same field. It's possible Mike Williams and Keenan Allen suit up on Sunday, too.

Bet: Over 50 Points (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.