NFL - Odds & Predictions

Chargers vs Cardinals Prediction, Odds & Best Bet for Week 12 Game (Defense Takes Backseat in Shootout)

Devon Platana
Los Angeles Chargers vs Arizona Cardinals prediction, odds and betting trends for NFL Week 12.
Los Angeles Chargers vs Arizona Cardinals prediction, odds and betting trends for NFL Week 12. / ASSOCIATED PRESS
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Chargers vs Cardinals Week 12 Game Info

2022 NFL Regular Season Game
Los Angeles Chargers (5-5, 3-2 Away) vs. Arizona Cardinals (4-7, 1-5 Home)
Date: Sunday, Nov. 27, 2022
Time: 4:05 p.m. ET
Venue: State Farm Stadium — Glendale, AZ
Coverage: CBS

Week 12 of the 2022 NFL season includes a west coast matchup between the Los Angeles Chargers and Arizona Cardinals. The Chargers' up-and-down season continued with a 30-27 loss to the rival Kansas City Chiefs last week, handing Brandon Staley's squad their third loss in the last four outings.

It's not like the Cardinals are doing any better, though. In fact, they also own a 1-3 record in their last four games following a 38-10 blowout loss to the San Francisco 49ers in Mexico City. Backup quarterback Colt McCoy filled in for the injured Kyler Murray, leaving time to tell if the veteran gunslinger will be given the task of facing the Chargers this weekend.

Chargers vs Cardinals Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LAC: (-152) | ARI: (+128)
Spread: LAC: -3 (-105) | ARI: +3 (-115)
Total: 48.5 —Over: (-114) | Under: (-106)

Updated (Sunday, Nov. 27, 11:40 a.m. EST): The Chargers enter this contest as clear favorites on the moneyline and spread on FanDuel Sportsbook's updated odds. This inter-conference clash also features an over/under of 48.5, which is the highest total on Sunday's slate.

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Chargers vs Cardinals Prediction & Pick

Neither of these teams has been easy to trust lately, however, the Cardinals are a different brand of "bad" at home. While teams are supposed to have an advantage in front of their own fans, Arizona is just 1-5 at State Farm Stadium in 2022, owning an embarrassing minus-7.2 point differential at home — third-worst in the NFL.

While the Chargers aren't perfect, they have won three of their last four away games and have a positive point differential on the road (plus-1.2, No. 10). I also love the idea of Los Angeles QB Justin Herbert surgically picking apart an Arizona secondary that gives up nearly 300 passing yards per game at home.

It's also going to be tough for the Cards to win if McCoy is back under center. His first appearance of the year was solid, but the same can't be said about last week, averaging just 6.4 passing yards per attempt with one interception and zero touchdowns. Even if Murray plays, it's worth mentioning that Arizona has lost four of his last five starts.

Barring any sort of collapse, the Chargers should win.

Final Score Prediction: Chargers: 30 | Cardinals: 24

Chargers vs Cardinals Betting Trends

- The Chargers are 5-0 against the spread (ATS) in their last five road games against Arizona.
- Arizona is 1-10 straight up in its last 11 home games.
- The total has hit the over in 11 of the Chargers' last 16 games.
- The total has hit the over in each of Arizona's five last games.

Chargers vs Cardinals Best Bet

I'm expecting a high-scoring affair when the Chargers and Cardinals collide. Even if each offense is missing parts, it doesn't change the fact that these two foes own bottom-four offenses this season.

With the total going over in 11 of the Chargers' last 16 games and in each of Arizona's last five, it's safe to say that viewers shouldn't worry about any offensive shortages.

Bet: Over 48.5 Points (-114)


Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.

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