Chargers vs Colts Prediction, Odds & Best Bets for Monday Night Football (LA's Defense Frustrates Indianapolis)

Larry Rupp
Los Angeles Chargers vs Indianapolis Colts prediction, odds and best bets for NFL Week 16 game.
Los Angeles Chargers vs Indianapolis Colts prediction, odds and best bets for NFL Week 16 game. / AP Photos/Marcio Jose Sanchez
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Chargers vs Colts Week 16 Game Info

2022 NFL Regular Season — Week 16
Los Angeles Chargers (8-6, 4-3 Away) vs. Indianapolis Colts (4-9-1, 2-4 Home)
Date: Monday, Dec. 26, 2022
Time: 8:15 p.m. ET
Venue: Lucas Oil Stadium — Indianapolis, IN
Coverage: ESPN

The Los Angeles Chargers will look to strenghten their lead in the AFC Wild Card race when they visit the Indianapolis Colts in Week 16 NFL action. The Chargers defeated the Tennessee Titans, 17-14, on Sunday. Running backs Austin Ekeler and Joshua Kelley were responsible for the two touchdowns.

Meanwhile, the Colts were on the wrong end of the biggest comeback in NFL history last Saturday. Indianapolis sported a 33-0 lead at halftime against the Minnesota Vikings before going on to lose in overtime by a score of 39-36. The defense simply could not get a single stop when it needed to.

Chargers vs Colts Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LAC: (-215) | IND: (+180)
Spread: LAC: -4.5 (-110) | IND: +4.5 (-110)
Total: 45.5 — Over: (-110) | Under: (-110)

The Chargers enter this contest as notable road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Monday night clash also features one of the higher totals on the Week 16 slate at 45.5 points.

Chargers vs Colts Prediction & Pick

It'll be interesting to see if the Colts are able to come out with some fire after losing in such deflating fashion in Week 15. Head coach Jeff Saturday has had his players pumped up ever since taking over, but this is as tough as it gets. The support of the home crowd will help, but it will just not be enough.

The Chargers have a chance to crush the Colts on Monday night. They have posted the second-highest passing play percentage in the NFL (66.7%) and average 274.2 yards through the air per game (No. 2 in NFL). Indianapolis just got torched for 460 passing yards and 4 TDs by Minnesota.

The Colts have lost four of their last five home games and don't have much left to fight for, so give me the Chargers.

Final Score Prediction: Chargers: 27 | Colts: 17

Chargers vs Colts Betting Trends

- The Chargers are 5-2 against the spread (ATS) in its last seven away games.
- The total has hit the under in five of the Chargers' last seven games.
- Indianapolis is 1-4 straight up in its last five games against the Chargers.
- The total has hit the over in four of Indianapolis' last five games.

Chargers vs Colts Best Bet

Indianapolis came out of nowhere to put up 36 points last week and looked like an entirely different offense. However, it's important to keep in mind that Minnesota's defense ranks as one of the worst in the NFL and the Vikings gave the Colts great field position with early turnovers. It was an outlier.

That won't happen this week. The Chargers have only logged 15 giveaways on the year (T-No. 6 in NFL) and have held two great offenses (Dolphins & Titans) to a combined 34 points over the last two weeks. The Colts have scored less than 21 points in a whopping 11 of their 14 games in 2022, too.

Bet: Indianapolis Colts Team Total Under 20.5 (-118)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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