NFL - Odds & Predictions

Chargers vs Chiefs Prediction, Odds & Betting Trends for NFL Week 2 Thursday Night Football on FanDuel Sportsbook

Larry Rupp
Los Angeles Chargers vs Kansas City Chiefs prediction, odds and betting trends for NFL Week 2 game.
Los Angeles Chargers vs Kansas City Chiefs prediction, odds and betting trends for NFL Week 2 game. / AP Photos/Peter Aiken

Chargers vs Chiefs Week 2 Game Info

2022 NFL Regular Season — Week 2 Thursday Night Football
Los Angeles Chargers (1-0, 0-0 Away) vs. Kansas City Chiefs (1-0, 0-0 Home)
Date: Thursday, September 15, 2022
Time: 8:15 p.m. ET
Venue: GEHA Field at Arrowhead Stadium — Kansas City, MO
Coverage: Prime Video

The Los Angeles Chargers will look to start 2-0 in the AFC West when they take on the Kansas City Chiefs on Thursday Night Football in Week 2. LA took down the Las Vegas Raiders by a score of 24-19 in Week 1 thanks to three passing touchdowns by third-year quarterback Justin Herbert.

Meanwhile, Kansas City crushed the Arizona Cardinals by a score of 44-21. Tight end Travis Kelce racked up 121 yards on eight receptions and running back Clyde Edwards-Helaire got into the end zone twice. Quarterback Patrick Mahomes stole the show with five passing touchdowns, though.

Charger vs Chiefs Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: LAC: (+150) | KC: (-178)
Spread: LAC: +3.5 (-114) | KC: -3.5 (-106)
Total: 53.5 — Over: (-114) | Under: (-106)

The Chiefs enter this contest as a small favorite on the moneyline and the spread. This Thursday night clash also features one of the higher projected totals (53.5) on the NFL Week 2 slate.

Chargers vs Chiefs Prediction & Pick

This head-to-head series has involved some thrillers over the last few years. In 2021, the Chargers shocked the Chiefs at Arrowhead when they earned an early season win by a score of 30-24. Kansas City then answered back in December when they emerged victorious in an overtime game, 34-28.

Overall, the Chargers are 3-13 straight up in their last 16 games against the Chiefs and Kansas City holds a 54-19 home record since 2013. Doubting the combination of Andy Reid and Mahomes is not something that has worked out very often. They'll get the job done here, but it'll take their best effort.

Final Score Prediction: Chargers: 27 | Chiefs: 31

Chargers vs Chiefs Betting Trends

- The Chargers are 1-4 straight up in their last five Week 2 games.
- The total has hit the over in four of the Chargers' last five away games.
- Kansas City is 8-3 against the spread (ATS) in its last 11 games.
- The total has hit the over in seven of Kansas City's last eight games.

Chargers vs Chiefs Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

A matchup between two of the best quarterbacks in the NFL should make for a high-scoring affair on national television. Herbert looked stellar in Week 1 as he avoided making any costly turnovers and completed 76.5% of his passes. On the other side, Mahomes seemed as dominant as ever in a big win.

The possibility of Keenan Allen being out may scare some bettors away from this high total, but keep in mind the over has hit in four of the Chargers' last five away games and seven of the Chiefs' last eight games overall.

Bet: Over 53.5 Points (-114)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.