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Cardinals vs Seahawks Prediction, Odds & Betting Trends for NFL Week 6 Game on FanDuel Sportsbook (Oct 16)

Larry Rupp
Arizona Cardinals vs Seattle Seahawks prediction, odds and betting trends for NFL Week 6 game.
Arizona Cardinals vs Seattle Seahawks prediction, odds and betting trends for NFL Week 6 game. / AP Photos/Paul Sancya
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Cardinals vs Seahawks Week 6 Game Info

2022 NFL Regular Season — Week 6
Arizona Cardinals (2-3, 2-0 Away) vs. Seattle Seahawks (2-3, 1-1 Home)
Date: Sunday, October 16, 2022
Time: 4:05 p.m. ET
Venue: Lumen Field — Seattle, WA
Coverage: FOX

Two teams vying for the NFC West title meet head-to-head in Week 6 as the Arizona Cardinals visit the Seattle Seahawks. The Cardinals lost a heartbreaker to the Philadelphia Eagles on Sunday as Matt Amendola missed a field goal with only seconds left on the clock. The final score was 20-17.

Meanwhile, the Seahawks failed to stop the New Orleans Saints from marching down the field time and time again in Week 5. Seattle fell by a final score of 39-32 and ruined what was another great showing from quarterback Geno Smith. Smith went 16-of-25 for 268 yards and 3 touchdowns.

Cardinals vs Seahawks Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: ARI: (-142) | SEA: (+120)
Spread: ARI: -2.5 (-112) | SEA: +2.5 (-108)
Total: 51.5 — Over: (-105) | Under: (-115)

The Cardinals enter this contest as a small road favorite on the moneyline and the spread. This 4:05 p.m. ET clash also features one of the higher totals on the Week 6 slate at 51.5 points.

Cardinals vs Seahawks Prediction & Pick

The Cardinals are a few plays away from having a winning record and being viewed as a sneaky NFC contender. The same thing cannot be said about the Seahawks, though, and that is because of their defense. Seattle is giving up a 30.8 points per game, which is the second-highest mark in the NFL.

This is the perfect time for Arizona to break their first quarter scoreless streak that has now stretched to five games. The trio of quarterback Kyler Murray, wide receiver Marquise Brown and tight end Zach Ertz should have no trouble finding the open gaps for big gains. Arizona wins this one comfortably.

Final Score Prediction: Cardinals: 31 | Seahawks: 21

Cardinals vs Seahawks Betting Trends

- Arizona is 10-2 against the spread (ATS) in its last 12 away games.
- The total has hit the under in seven of Arizona's last 10 games.
- Seattle is 6-3 straight up in its last nine games played in Week 6.
- The total has hit the over in four of Seattle's last six games against Arizona.

Cardinals vs Seahawks Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

While the Seahawks' defense has been the source of their downfalls, the Cardinals' defense has performed quite well so far. They own the 12th-best rush defense DVOA rating in the league and are allowing only 97.4 yards per game on the ground (No. 5 in NFL). The defensive line has been feasting.

That's why it's surprising to see the Cardinals not favored by more than a field goal. Arizona is 10-2 against the spread (ATS) in its last 12 away games and 6-3 ATS in its last nine games against Seattle. On the other side, the Seahawks are 3-6 ATS in their last nine games against a NFC West opponent.

Bet: Arizona Cardinals -2.5 (-112)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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