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Cardinals vs Raiders Prediction, Odds & Betting Trends for NFL Week 2 Game on FanDuel Sportsbook (Sept 18)

Devon Platana
Arizona Cardinals vs Las Vegas Raiders prediction, odds and betting trends for NFL regular season game.
Arizona Cardinals vs Las Vegas Raiders prediction, odds and betting trends for NFL regular season game. / (AP Photo/John Locher)
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Cardinals vs Raiders Week 2 Game Info

2022 NFL Regular Season Game
Arizona Cardinals (0-1, 0-0 Away) vs. Las Vegas Raiders (0-1, 0-0 Home)
Date: Sunday, Sept. 18, 2022
Time: 4:25 p.m. ET
Venue: Allegiant Stadium — Las Vegas, NV
Coverage: CBS

Week 2 of the 2022 NFL season includes a showdown between the Arizona Cardinals and Las Vegas Raiders. The Cardinals enter the week after a 44-21 loss to the Kansas City Chiefs that saw Kliff Kingsbury's squad get outscored 37-7 through the first three quarters. Needless to say, a stronger effort will be needed at Allegiant Stadium.

Meanwhile, the Raiders dropped their season opener, 24-19, to the Los Angeles Chargers. While the loss is unfortunate, Las Vegas fans expect better results after Derek Carr and Davante Adams proved that they still have their college chemistry, resulting in 141 receiving yards and a touchdown for the All-Pro wideout.

Cardinals vs Raiders Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: ARI: (+190) | LV: (-230)
Spread: ARI: +5.5 (-110) | LV: -5.5 (-110)
Total: 51.5 — Over: (-110) | Under: (-110)


Updated (Sunday, Sept. 18, 12:35 p.m. EST): The Raiders enter this contest as the favorite on the moneyline and the spread, both of which have held mostly steady on FanDuel Sportsbook's updated odds. This 4:25 p.m. ET clash also features a total of 51.5, which is the highest total on Sunday and Monday's slates.

Cardinals vs Raiders Prediction & Pick

If the Cardinals don't fix their defensive issues, things could quickly get ugly on Sunday. Arizona allowed Patrick Mahomes to throw for 360 yards and five touchdown passes. While Carr isn't on Mahomes' level, he can do plenty of damage through the air if given the opportunity thanks to the likes of Adams, Darren Waller and Hunter Renfrow.

Forgetting about defense, Arizona's offense wasn't great either. Fourteen of the Cardinals' 21 points came in the fourth quarter when the Chiefs weren't trying anymore. DeAndre Hopkins' presence is clearly missed in the passing game and it also doesn't help that the Cards only converted on 3-of-12 third-down attempts.

While the Raiders have their own areas to improve, they didn't look nearly as underwhelming as the Cardinals. With the game also being played at Allegiant Stadium, I like the Raiders' chances of getting their first win of 2022.

Final Score Prediction: Raiders: 28 | Cardinals: 21

Cardinals vs Raiders Betting Trends

- Arizona is 1-6 straight up in its last seven games.
- Las Vegas is 5-2 against the spread (ATS) in its last seven games against Arizona.
- The total has hit the under in five of Arizona's last seven games against AFC teams.
- The total has hit the under in five of Las Vegas' last six games.

Cardinals vs Raiders Best Bet

I like the Raiders more here, but an outright bet isn't playable. Fortunately, Las Vegas tends to play well against the spread when Arizona is involved, going 5-2 ATS in their last seven meetings. With the Cardinals' defense being as bad as it was last week, expect the Raiders to cover the 4.5-point spread.

Bet: Raiders -5.5 (-110)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

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