Cardinals vs Reds Prediction, Odds & Best Bet for May 22 (St. Louis Builds Momentum Behind Powerful Bats)

St. Louis Cardinals vs Cincinnati Reds prediction, odds and betting insights for MLB regular season game.
St. Louis Cardinals vs Cincinnati Reds prediction, odds and betting insights for MLB regular season game. / AP Photos/Michael Dwyer
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The St. Louis Cardinals (21-27) will aim to keep climbing in the NL Central standings when they visit the Cincinnati Reds (19-27) in the first matchup of their four-game series on Monday, May 22.

Cardinals vs Reds Game Info

  • Date: Monday, May 22, 2023
  • Time: 6:40 p.m. ET
  • Venue: Great American Ball Park -- Cincinnati, OH
  • Coverage: BSOH and BSMW

It has been far from a great start to the season for the Cardinals, but their 8-2 record over their last 10 games has helped them get back on track in the division. Meanwhile, the Reds have started to take a step back and are coming off a series in which they were swept at home by the New York Yankees.

Cardinals vs Reds Odds & Spread

  • All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
  • Moneyline: STL: (-190) | CIN: (+160)
  • Spread: STL: -1.5 (-120) | CIN: +1.5 (+100)
  • Total: 10 -- Over: (-118) | Under: (-104)

The Cardinals enter this contest as clear road favorites on the moneyline and spread per FanDuel Sportsbook's odds. This 6:40 p.m. ET clash also features an over/under of 10 runs with the over favored at -118 odds.

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Cardinals vs Reds Betting Trends

  • St. Louis is 5-1 straight up in its last six away games.
  • The total has hit the over in 12 of St. Louis' last 18 games.
  • Cincinnati is 2-4 straight up in its last six games against St. Louis.
  • The total has hit the under in four of Cincinnati's last five home games.

Cardinals vs Reds Prediction & Pick

It's a battle of southpaws in Cincinnati on Monday as Jordan Montgomery and Brandon Williamson take the mound. Montgomery has quietly been the Cardinals' most reliable starter, posting a 4.21 ERA and 1.34 WHIP across nine starts. His 2-6 record is more reflective of the lack of run support he gets.

Williamson is making only his second career start. The 25-year-old impressed during his MLB debut against the Colorado Rockies, giving up 1 earned run on 2 hits and 2 walks over 5.2 innings. He now faces a Cardinals lineup that ranks fifth in slugging percentage against left-handers, though (.461).

Not only that, but St. Louis also enters Monday night fifth in home runs (67). Facing a lineup full of power hitters like Paul Goldschmidt and Nolan Arenado could be troublesome for a young pitcher used to facing Triple-A talent. I'll back the Cardinals to stay hot with a road victory in Cincinnati.

Final Score Prediction: Cardinals: 6 | Reds: 4

Cardinals vs Reds Best Bet

Nolan Arenado has been power surge as of late, hitting a home run in six of his St. Louis' last 10 games. He has destroyed left-handed pitching in 2023 as well, posting a respectable slash line of .306/.381/.722 to go along with 4 home runs in 42 plate appearances. Arenado has hit 7 career home runs at Great American Ballpark and I like his chances of increasing that mark against a young pitcher.

Bet: Nolan Arenado to Hit a Home Run (+280)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.