Buccaneers vs Cardinals Prediction, Odds & Best Bet for Sunday Night Football (Bucs Break Out of Offensive Funk)

Devon Platana
Tampa Bay Buccaneers vs Arizona Cardinals prediction, odds and betting trends for NFL Week 16.
Tampa Bay Buccaneers vs Arizona Cardinals prediction, odds and betting trends for NFL Week 16. / ASSOCIATED PRESS
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Buccaneers vs Cardinals Week 16 Game Info

2022 NFL Regular Season Game
Tampa Bay Buccaneers (6-8, 2-4 Away) vs. Arizona Cardinals (4-10, 1-7 Home)
Date: Sunday, Dec. 25, 2022
Time: 8:20 p.m. ET
Venue: State Farm Stadium — Glendale, AZ
Coverage: NBC

Week 16 of the 2022 NFL season features a slate of Christmas Day matchups, including a Sunday Night Football battle between the Tampa Bay Buccaneers and Arizona Cardinals.

Despite their best efforts, the Buccaneers picked up another loss last week, falling 34-23 to the Cincinnati Bengals at Raymond James Stadium. The Cardinals didn't have any success either in Week 15, losing 24-15 to the Denver Broncos to mark the former's fourth straight loss.

Can the Buccaneers grab their first road win since Week 2? Or do the Cardinals have what it takes to win for just the second time at home this season?

Buccaneers vs Cardinals Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: TB (-255) | ARI: (+210)
Spread: TB: -6 (-110) | ARI: +6 (-110)
Total: 41.5 —Over: (-108) | Under: (-112)

The Buccaneers enter this contest as clear road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Sunday Night Football matchup also features an over/under of 41.5, which is right in the middle of the Week 16 totals. 

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Buccaneers vs Cardinals Prediction & Pick

The Cardinals have been inconsistent this year, but they've taken things to a new low since Kyler Murray's season-ending ACL tear. Backup quarterbacks Colt McCoy and Trace McSorely have gone a combined 47-of-76 for 368 passing yards with four interceptions and zero touchdowns in Murray's absence.

Although the Bucs have also had their struggles, I'm confident that Tom Brady can out-duel whichever Cardinals QB is under center. After all, the seven-time Super Bowl Champion was somewhat productive against the Bengals (312 passing yards, three TDs, two INTs) and should be able to take advantage of an Arizona defense that surrenders the most points and 10th-most passing yards.

A loss here would also guarantee a losing season for Tampa Bay, so look for the Buccaneers to edge out a victory on the road.

Final Score Prediction: Buccaneers: 24 | Cardinals: 13

Buccaneers vs Cardinals Betting Trends

- Tampa Bay is 7-3 straight up in its last 10 games played in December.
- Arizona is 1-12 straight up in its last 13 home games.
- The total has hit the under in 10 of Tampa Bay's last 14 games.
- The total has hit the under in eight of Arizona's last 12 games against Tampa Bay.

Buccaneers vs Cardinals Best Bet

The idea of "home-field advantage" may as well be a myth for the Cardinals this season. Not only have they lost seven of eight at State Farm Stadium thus far, but they also allow the 11th-most points at home (28.7 PPG) with the second-worst scoring margin (minus-7.3).

The Buccaneers aren't perfect by any stretch, but they have enough offensive talent to win this one by more than a touchdown. With Arizona showing zero signs of life at home, look for Tampa Bay to cover the spread due to one of its better offensive performances this campaign.

Bet: Buccaneers -6 (-110)


Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.

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