NFL - Odds & Predictions

Browns vs Bills Opening Odds, Betting Lines & Prediction for Week 11 Game on FanDuel Sportsbook

Isaiah De Los Santos
Browns vs Bills NFL opening odds, lines and predictions for Week 11 game on FanDuel Sportsbook.
Browns vs Bills NFL opening odds, lines and predictions for Week 11 game on FanDuel Sportsbook. / (AP Photo/Jeffrey T. Barnes)

Week 10 NFL action is underway, but FanDuel Sportsbook has already released NFL odds and lines for Week 11, giving us an early preview of the upcoming slate.

Week 11 includes an AFC showdown between the Cleveland Browns and Buffalo Bills.

Browns vs Bills Odds & Lines Week 11

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: CLE: (+250) | BUF: (-310)
Spread: CLE: +7.5 (-110) | BUF: -7.5 (-110)
Total: N/A — Over: (N/A) | Under: (N/A)

The Browns are projected as underdogs on the road in Week 11. Buffalo is an early -310 moneyline favorite and favored by 7.5 points on the spread.

Browns vs Bills Prediction Week 11

Early NFL predictions and picks are from ESPN's Football Power Index (FPI).
Browns: 19.8% to win
Bills: 80.0% to win

The Browns have the offense to hang with Buffalo, but the difference between these defenses will likely be the deciding factor. The Bills have hounded opposing teams in 2022, allowing the fourth-fewest total yards per game. They're built to stop a Cleveland offense that relies on its rushing attack, which will put extra pressure on Jacoby Brissett to crack a secondary that's getting healthier. Buffalo's got the edge in nearly aspect and should be handle to handle the Browns. Bet Bills -7.5 (-110).

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Isaiah De Los Santos is not a FanDuel employee. In addition to providing DFS gameplay advice, Isaiah De Los Santos also participates in DFS contests on FanDuel using his personal account, username zayyy05328. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.