Broncos vs Seahawks Prediction, Odds & Betting Trends for NFL Week 1 Monday Night Football on FanDuel Sportsbook

Denver Broncos vs Seattle Seahawks prediction, odds and betting trends for NFL regular season game.
Denver Broncos vs Seattle Seahawks prediction, odds and betting trends for NFL regular season game. / ASSOCIATED PRESS

Broncos vs Seahawks Week 1 Game Info

2022 NFL Regular Season Game
Denver Broncos (0-0, 0-0 Away) vs. Seattle Seahawks (0-0, 0-0 Home)
Date: Monday, Sept. 12, 2022
Time: 8:15 p.m. ET
Venue: Lumen Field — Seattle, WA
Coverage: ESPN, ABC

Week 1 of the 2022 NFL season includes a showdown between the Denver Broncos and Seattle Seahawks. It's no secret that this is one of the most anticipated first-week tilts as it marks the Broncos quarterback Russell Wilson's return to Seattle after spending 10 seasons as the Seahawks' signal-caller.

Both teams are heading in opposite directions, though. On one hand, the Broncos are poised to be one of the AFC's top threats as they look to return to the Super Bowl for the first time since 2015. On the other, the Seahawks are in a rebuild and will likely be less competitive with Geno Smith under center.

Broncos vs Seahawks Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: DEN: (-270) | SEA: (+220)
Spread: DEN: -6.5 (-110) | SEA: +6.5 (-110)
Total: 44.5 — Over: (-110) | Under: (-110)

Updated (Thursday, Sept. 8, 3:30 p.m. ET): The odds for this game have shifted slightly since they opened. Seattle has gone from +210 to +220 on the moneyline now, while the Broncos increased from -255 to -270. Denver remains a 6.5-point favorite.

The Broncos enter this contest as the favorite on the moneyline and the spread. This 8:15 p.m. ET clash also features a total of 42.5, which is fairly low compared to this week's NFL projected totals.

Broncos vs Seahawks Prediction & Pick

Don't let the Wilson return story distract from the fact that there's a mismatch here. The Seahawks aren't even close to being on the Broncos' level in their current form and it's tough to imagine Drew Lock keeping pace with Wilson throughout all 60 minutes.

The Broncos have also performed well against Seattle in recent history, going 13-5 straight up in the last 18 clashes between the two teams. With Denver having the advantage in just about every category, I can't see the Broncos losing here — especially after all of their offseason improvements.

Final Score Prediction: Broncos: 28 | Seahawks: 13

Broncos vs Seahawks Betting Trends

- Denver is 5-1 against the spread (ATS) in its last six games against NFC teams.
- Seattle is 13-7 ATS in its last 20 games as the underdog.
- The total has hit the under in 10 of Denver's last 14 road games against Seattle.
- The total has hit the over in five of Seattle's last six games.

Broncos vs Seahawks Best Bet

All NFL betting lines, odds and prop bets are available on FanDuel Sportsbook.

With the Broncos having a vastly superior roster, I expect them to put things out of reach early on. Even with the home crowd cheering them on, the Seahawks don't look like anything special this year, leading to Denver covering the 6.5-point spread on Monday.

Bet: Broncos -6.5 (-110)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.