Bills vs Chiefs Prediction, Odds & Betting Trends for NFL Week 6 Game on FanDuel Sportsbook

Bills vs Chiefs Week 6 Game Info

2022 NFL Regular Season Game
Buffalo Bills (4-1, 2-1 Away) vs. Kansas City Chiefs (4-1, 2-0 Home)
Date: Sunday, Oct. 16, 2022
Time: 4:25 p.m. ET
Venue: GEHA Field at Arrowhead Stadium — Kansas City, MO
Coverage: CBS

Week 6 of the 2022 NFL season includes a juicy matchup between AFC contenders as the Buffalo Bills travel to face the Kansas City Chiefs. The Bills enter the week coming off a 38-3 blowout win over the Pittsburgh Steelers.

The Chiefs were also victorious in Week 5 with a 30-29 victory against the Las Vegas Raiders on Monday. These teams are tied for the top record in the AFC at 4-1, meaning the winner will take control of the No. 1 seed.

Bills vs Chiefs Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (-146) | KC: (+124)
Spread: BUF: -2.5 (-118) | KC: +2.5 (-104)
Total: 53.5 —Over: (-115) | Under: (-105)

The Bills enter this contest as small road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This 4:25 p.m. ET clash also features a total of 53.5, which is currently the highest of the projected Week 6 totals.

Bills vs Chiefs Prediction & Pick

The Bills and Chiefs are two of the top teams that the NFL has to offer, so fans should expect them to deliver an entertaining game. Having said that, only one team can emerge as the victor and I'm predicting that will be Buffalo.

There's no denying how good Kansas City is when the ball is in Patrick Mahomes' hands, but the Bills own the best defense in the NFL. Mahomes is nearly impossible to shut down, but if they at least slow him down that should be enough.

There's also the fact that the Chiefs' defense is absolutely dreadful, giving up the 10th-most points in the NFL at 25.0 per game. Josh Allen is already looking to avenge back-to-back postseason losses against Kansas City, so a weak defense won't help the Chiefs' case here.

As the offenses put on the show, I expect the Bills' defense to get crucial stops when needed, leading to a Buffalo victory.

Final Score Prediction: Bills: 35 | Chiefs: 27

Bills vs Chiefs Betting Trends

- Buffalo is 5-1-1 against the spread (ATS) in its last seven games as the favorite.
- Kansas City is 1-4 ATS in its last five games against the AFC.
- The total has hit the over in five of Buffalo's last six road games against Kansas City.
- The total has hit the over in 10 of Kansas City's last 13 games.

Bills vs Chiefs Best Bet

Again, people should expect a high-scoring affair whenever the league's top offenses meet. The last three Bills vs. Chiefs matchups have averaged 66 total points with each outing surpassing this week's 53.5-point total.

With Mahomes and Allen looking to outdo each other, expect another shootout that ends up hitting the Over.

Bet: Over 53.5 Points (-115)

Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.