Bills vs Bengals Prediction, Odds & Best Bet for Monday Night Football (Buffalo, Cincy Collide in MNF Shootout)

Devon Platana
Buffalo Bills vs Cincinnati Bengals prediction, odds and betting trends for NFL Week 17.
Buffalo Bills vs Cincinnati Bengals prediction, odds and betting trends for NFL Week 17. / (AP Photo/Jeffrey T. Barnes)
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Bills vs Bengals Week 17 Game Info

2022 NFL Regular Season Game
Buffalo Bills (12-3, 6-2 Away) vs. Cincinnati Bengals (11-4, 5-1 Home)
Date: Monday, Jan. 2, 2023
Time: 8:30 p.m. ET
Venue: Paycor Stadium — Cincinnati, OH
Coverage: ESPN, ABC, ESPN2, ESPN+

Week 17 of the 2022 NFL season features an exciting slate of matchups, including a massive Monday Night Football showdown between the Buffalo Bills and Cincinnati Bengals.

Winners in six straight outings, the Bills kept the momentum going with a 35-13 blowout victory over the lowly Chicago Bears on Christmas Eve. Meanwhile, the Bengals have won seven straight games and nine of their last 10, tallying a 22-18 win against the New England Patriots in Week 16.

Can the Bills continue their quest to clinch the AFC's No. 1 spot? Or will the Bengals play spoiler with the hometown crowd cheering them on?

Bills vs Bengals Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF (-116) | CIN: (-102)
Spread: BUF: -1.5 (-105) | CIN: +1.5 (-115)
Total: 49.5 —Over: (-110) | Under: (-110)

The Bills enter this contest as slight road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Monday Night Football matchup also features an over/under of 49.5, which is one of the highest Week 17 totals. 

Bills vs Bengals Prediction & Pick

Winning at Paycor Stadium has been tough for visiting teams, but if any squad can get the win in Cincinnati, it's the Bills. They're one of the best road teams in the NFL, averaging 25.8 points (No. 5), 392.8 total yards (No. 3) and a plus-7.8 scoring margin in away matchups this season.

I also like the Bills' chances of getting stops when they matter the most. They hold opponents to a 37.9% third-down conversion percentage (No. 11) while the Bengals have held the opposition to a 39.8% rate. While that's not the biggest difference, it's worth noting that the Patriots converted on 46.2% of third downs against Cincinnati.

The Bills also average 1.6 takeaways per game (T-No. 4) and have generated 39 sacks thus far (No. 11), proving that it will be a rough day for Joe Burrow and the Bengals' offense. As long as Buffalo's defenders can take advantage of any Cincinnati miscues, the Bills should win this one.

Final Score Prediction: Bills: 31 | Bengals: 28

Bills vs Bengals Betting Trends

- Buffalo is 12-4 straight up in its last 16 games against Cincinnati.
- Cincinnati is 5-0 against the spread (ATS) in its last five home games.
- The total has hit the over in eight of Buffalo's last 11 road games against Cincinnati.
- The total has hit the under in four of Cincinnati's last five games.

Bills vs Bengals Best Bet

With two high-flying teams set to collide, it's hard not to back the over on the 49.5-point total. After all, two of the NFL's top-six offenses will be present, averaging a combined 56.0 PPG. Quarterbacks Josh Allen and Joe Burrow will definitely want to outduel the other as well, which could lead to more points being scored than expected.

Additionally, eight of the last 11 Bills-Bengals matchups played in Cincinnati have hit the over. Both teams could use a massive victory with the playoffs being right around the corner, too, further cementing my belief that more than 49.5 points will be scored Monday night.

Bet: Over 49.5 (-110)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

Game odds refresh periodically and are subject to change.

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