Bills vs Panthers Prediction, Odds & Betting Trends for NFL Preseason Game on FanDuel Sportsbook (Aug 26)

Buffalo Bills vs Carolina Panthers prediction, odds and betting trends for NFL preseason game.
Buffalo Bills vs Carolina Panthers prediction, odds and betting trends for NFL preseason game. / AP Photo/Adrian Kraus

Bills vs Panthers Preseason Game Info

2022 NFL Preseason Game
Buffalo Bills (2-0) vs. Carolina Panthers (1-1)
Date: Friday, August 26, 2022
Time: 7 p.m. ET
Venue: Bank of America Stadium — Charlotte, NC

Week 3 of the NFL preseason includes a showdown between the Buffalo Bills on Friday night. The Bills are absolutely buzzing following a massive 42-15 victory over the Denver Broncos this past weekend. It was an all-around team effort that involved Buffalo racking up 208 rushing yards on 27 carries.

The Panthers, on the other hand, weren't as lucky last week. Though Matt Rhule's team led 3-0 after the first quarter, it was all the New England Patriots from there, eventually beating Carolina by a final score of 20-10.

Bills vs Panthers Odds & Spread

All NFL preseason betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: BUF: (+220) | CAR: (-270)
Spread: BUF: +6 (-110) | CAR: -6 (-110)
Total: 42 — Over: (-115) | Under: (-105)

The Panthers enter this contest as the favorite on the moneyline and the spread. This 7 p.m. ET clash also features a total of 42, which is higher compared to this week's other NFL projected totals.

Bills vs Panthers Prediction & Pick

Though the Bills have been dominant this preseason, there isn't much of a reason for them to try their hardest to beat the Panthers. Most of Buffalo's major position battles are settled and it won't be shocking if Sean McDermott rests most of his starters, if not all of them.

Meanwhile, the Panthers will have a slight edge due to them likely playing more of their starters. The Bills' defenders should keep things close, however, Carolina's players have more riding on the line as they battle for a 53-man roster spot, needing their best effort to crack the lineup.

Final Score Prediction: Panthers: 24 | Bills: 20

Bills vs Panthers Betting Trends

- Buffalo is 6-2-1 against the spread (ATS) in its last nine games against Carolina.
- Carolina is 1-8 ATS in their last nine games.
- The total has hit the over in six of Buffalo's last eight road games.
- The total has hit the over in six of Carolina's last seven games against Buffalo.

Bills vs Panthers Best Bet

All NFL preseason betting lines, odds and prop bets are available on FanDuel Sportsbook.

There isn't much value to be had with an outright Panthers win, so I'm looking to the total here. Both teams have combined for the over more often than not in their recent meetings. Even if Buffalo rests key players, the Bills and Panthers have enough talent to surpass the 42-point projected total.

Bet: Over 42 Points (-115)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.