Athletics vs Mariners Prediction, Odds & Best Bet for May 22 (Seattle's Offense Wakes Up at T-Mobile Park)

Oakland Athletics vs Seattle Mariners prediction, odds and betting insights for MLB regular season game.
Oakland Athletics vs Seattle Mariners prediction, odds and betting insights for MLB regular season game. / AP Photos/Paul Sancya

The Seattle Mariners (22-24) will look to make up ground in a tough AL West division when they host the Oakland Athletics (10-38) in the first matchup of their four-game series on Monday, May 22.

Athletics vs Mariners Game Info

  • Date: Monday, May 22, 2023
  • Time: 9:40 p.m. ET
  • Venue: T-Mobile Park -- Seattle, WA
  • Coverage: NBCSCA and ROOTNW

This is a pair of divisional opponents that know one another quite well as Oakland and Seattle have met head-to-head 41 times since the start of the 2021 MLB season. The Mariners own a dominant record of 29-12 during that span and have already swept the Athletics once this year to begin May.

Athletics vs Mariners Odds & Spread

  • All MLB betting lines, odds and prop bets are from FanDuel Sportsbook.
  • Moneyline: OAK: (+270) | SEA: (-335)
  • Spread: OAK: +1.5 (+128) | SEA: -1.5 (-154)
  • Total: 7.5 -- Over: (-122) | Under: (+100)

The Mariners enter this contest as heavy home favorites on the moneyline and spread per FanDuel Sportsbook's odds. This 9:40 p.m. ET clash also features an over/under of 7.5 runs with the over favored at -122 odds.

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Athletics vs Mariners Betting Trends

  • Oakland is 0-7 straight up in its last seven away games.
  • The total has hit the under in five of Oakland's last six games.
  • Seattle is 6-1 straight up in its last seven games against Oakland.
  • The total has hit the under in four of Seattle's last five home games.

Athletics vs Mariners Prediction & Pick

Oakland will look to get back in the in column with Kyle Muller on the mound. The 25-year-old has struggled to find his groove, though, as he owns a 7.71 ERA and 1.95 WHIP across nine starts (1-3 record). He has given up at least 5 earned runs in each of his last three starts for the Athletics, too.

The Mariners will counter with Luis Castillo, who has simply been lights out when pitching at T-Mobile Park. It's a stadium where he has posted a 2.00 ERA and 0.80 WHIP in 11 career starts (4-1 record). The All-Star hurler is averaging 10.1 strikeouts per nine innings, which is an improvement from 2022.

Without either one of these offenses showing much promise this season, diving into the work on the mound is even more important. Seattle owns a team ERA of 3.36 at home this year (No. 5 in MLB), while Oakland owns the worst team ERA on the road of any MLB team (8.05). This one could get ugly.

Final Score Prediction: Athletics: 2 | Mariners: 6

Athletics vs Mariners Best Bet

Much of the reasoning behind this best bet has been explained above. The Athletics give up an insane amount of runs when away from home and have a pitcher on the mound that has been struggling to say the least. The Mariners are in need of an offensive outbreak and now get to face an opponent in which they have aleady scored at least 5 runs against in two of three matchups this year.

Bet: Seattle Mariners Over 5 Runs (-104)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.