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49ers vs Vikings Prediction, Odds & Betting Trends for NFL Preseason Game on FanDuel Sportsbook (Aug 20)

Devon Platana
San Francisco 49ers vs. Minnesota Vikings prediction, odds and betting trends for NFL preseason game.
San Francisco 49ers vs. Minnesota Vikings prediction, odds and betting trends for NFL preseason game. / AP Photo/Jed Jacobsohn
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49ers vs Vikings Preseason Game Info

2022 NFL Preseason Game
San Francisco 49ers (1-0) vs. Minnesota Vikings (0-1)
Date: Saturday, August 20, 2022
Time: 7 p.m. ET
Venue: U.S. Bank Stadium — Minneapolis, MN

Week 2 of the NFL preseason includes a showdown between the San Francisco 49ers and Minnesota Vikings. Momentum is on the 49ers' side following a 28-21 victory over the Green Bay Packers this past weekend. San Francisco had a steady amount of pressure rolling throughout their win, needing a similar effort to beat the Vikings.

Speaking of the Vikings, they're hungry for success after opening their preseason with a 26-20 loss to the Las Vegas Raiders. Racking up 71 yards over eight penalties was one key factor in Minnesota's downfall, so more discipline is needed to win at U.S. Bank Stadium this weekend.

49ers vs Vikings Odds & Spread

All NFL preseason betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (+175) | MIN: (-210)
Spread: SF: +4.5 (-110) | MIN: -4.5 (-110)
Total: 41.5 — Over: (-110) | Under: (-110)

The Vikings enter this contest as the favorite on the moneyline and the spread. This 8 p.m. ET clash also features a total of 41.5, which is higher than most of this week's NFL projected totals.

49ers vs Vikings Prediction & Pick

The 49ers have been one of the better preseason teams in recent years. Following last week's victory, San Francisco has now won six of its last eight exhibition contests. Nevertheless, the trend may not continue if Kyle Shanahan can't get his defense to tighten up after allowing the Packers to tally 437 total yards.

Meanwhile, the Vikings have been atrocious in the preseason. In addition to losing each of their last five exhibition contests, they're also 1-4 against the spread (ATS) over that stretch. Throw in the team's discipline issues and there isn't a real reason to like them as a betting option this week.

I think the 49ers stay in the win column here.

Final Score Prediction: 49ers: 28 | Vikings: 17

49ers vs Vikings Betting Trends

- San Francisco is 5-1 against the spread (ATS) in its last six games against Minnesota.
- Minnesota is 1-4 ATS in its last five games played on Saturday.
- The total has hit the under in seven of San Francisco's last 10 games against Minnesota.
- Minnesota is 3-6 straight up in its last nine games against San Francisco.

49ers vs Vikings Best Bet

All NFL preseason betting lines, odds and prop bets are available on FanDuel Sportsbook.

Although the 49ers have performed well ATS in their recent meetings with the Vikings, there isn't much value to be had there. On the flip side, taking San Francisco at +175 odds on the moneyline could yield a decent return, assuming the 49ers continue their success against the Vikings.

Bet: 49ers ML (+175)

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Devon Platana is not a FanDuel employee. In addition to providing DFS gameplay advice, Devon Platana also participates in DFS contests on FanDuel using his personal account, username PepeSilvia0. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel.

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