NFL - Odds & Predictions

49ers vs Texans Prediction, Odds & Betting Trends for NFL Preseason Game on FanDuel Sportsbook (Aug 25)

Larry Rupp
San Francisco 49ers vs Houston Texans prediction, odds and betting trends for NFL preseason game.
San Francisco 49ers vs Houston Texans prediction, odds and betting trends for NFL preseason game. / AP Photos/Craig Lassig
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49ers vs Texans Preseason Game Info

2022 NFL Preseason Game
San Francisco 49ers (2-0) vs. Houston Texans (2-0)
Date: Thursday, August 25, 2022
Time: 8:15 p.m. ET
Venue: NRG Stadium — Houston, TX
Coverage: Prime Video

The San Francisco 49ers and Houston Texans meet head-to-head in NFL preseason action on Thursday night. The 49ers have won each of their first two preseason games by at least seven points and their defense nabbed two interceptions against the Minnesota Vikings its last time out.

Meanwhile, the Texans are also unbeaten in the preseason thanks to close wins over the New Orleans Saints and Los Angeles Rams. Houston's 24-20 win last weekend was fueled by efforts from all three of their quarterbacks. Davis Mills, Kyle Allen and Jeff Driskel each logged a touchdown pass.

49ers vs Texans Odds & Spread

All NFL preseason betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-190) | HOU: (+160)
Spread: SF: -3.5 (-115) | HOU: +3.5 (-105)
Total: 39.5 — Over: (-110) | Under: (-110)

The 49ers enter this contest as a clear favorite on the moneyline and the spread. This 8:15 p.m. ET clash also features the same total as Thursday's only other preseason game.

49ers vs Texans Prediction & Pick

Many people were surprised to see quarterback Trey Lance not play a single snap for the 49ers last week. After all, this is a guy that saw limited snaps as a rookie. He is in desperate needs of reps, but head coach Kyle Shanahan looks poised to keep his new starter rested ahead of the regular season.

That means Houston has an edge to start the game with second-year pro Davis Mills set to play in a few series. The 23-year-old controlled the pace against the Rams last weekend as he completed 10 of his 17 pass attempts for 96 yards and one touchdown. He'll do enough to grab a big upset win.

Final Score Prediction: 49ers: 20 | Texans: 27

49ers vs Texans Betting Trends

- San Francisco is 5-0 against the spread (ATS) in its last five away games.
- The total has hit the under in eight of San Francisco's last 10 games.
- Houston is 3-11 straight up in its last 14 home games.
- The total has hit the under in each of Houston's last five games against San Francisco.

49ers vs Texans Best Bet

All NFL preseason betting lines, odds and prop bets are available on FanDuel Sportsbook.

It's not like the 49ers are lost without Trey Lance leading the offense. Backups Brock Purdy and Nate Sudfeld combined to go 27-of-40 for 230 yards and 1 touchdown against the Vikings. San Francisco also averaged 4.2 yards per carry, so it's clear Shanahan knows how to get the best out of his players.

On the other side, the Texans have tallied 41 points through two preseason wins and have a pair of veteran quarterbacks ready to relieve Mills in Driskel and Allen. They have combined to start 26 NFL regular games in their careers. Two competent offense means this contest should fly past the 40-point mark.

Bet: Over 39.5 Points (-110)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

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