49ers vs Seahawks Prediction, Odds & Best Bets for Thursday Night Football (San Francisco Clinches NFC West Title)

Larry Rupp
San Francisco 49ers vs Seattle Seahawks prediction, odds and best bets for NFL Week 15 game.
San Francisco 49ers vs Seattle Seahawks prediction, odds and best bets for NFL Week 15 game. / AP Photos/Jed Jacobsohn
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49ers vs Seahawks Week 15 Game Info

2022 NFL Regular Season — Week 15
San Francisco 49ers (9-4, 3-3 Away) vs. Seattle Seahawks (7-6, 3-3 Home)
Date: Thursday, Dec. 15, 2022
Time: 8:15 p.m. ET
Venue: Lumen Field — Seattle, WA
Coverage: Prime Video

NFC West rivals meet head-to-head in Week 15 as the San Francisco 49ers visit the Seattle Seahawks. The 49ers extended their winning streak to six games with a 35-7 win over the Tampa Bay Buccaneers on Sunday. Quarterback Brock Purdy went 16-of-21 for 185 yards and 2 touchdowns.

Meanwhile, the Seahawks faltered in a 30-24 loss to the Carolina Panthers in Week 14. Seattle fell into an early hole thanks to a costly interception thrown by quarterback Geno Smith. Carolina controlled the clock with the ground game (223 rushing yards) and landed a brutal blow in the Wild Card race.

49ers vs Seahawks Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-184) | SEA: (+154)
Spread: SF: -3.5 (-106) | SEA: +3.5 (-114)
Total: 43.5 — Over: (-110) | Under: (-110)

The 49ers enter this contest as small road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This Thursday night clash also features one of the lower totals on the Week 15 slate at 43.5 points.

49ers vs Seahawks Prediction & Pick

The emergence of Brock Purdy is real. The last pick of the 2022 NFL Draft has played well in head coach Kyle Shanahan's system and hasn't made the typical mistakes that rookies do. San Francisco has a shot to clinch the NFC West title on Thursday night, so look for everything to be left on the field.

Seattle is hanging onto a playoff spot, but not even that bit of hope can save this defense right now. The Seahawks have allowed an average of 407.7 yards over their last three games (No. 28 in NFL) and just gave up 223 rushing yards to the Panthers. Christian McCaffrey should be in for a huge game.

I expect the 49ers to finish off the season sweep after torching the Seahawks, 27-7, back in Week 2.

Final Score Prediction: 49ers: 24 | Seahawks: 17

49ers vs Seahawks Betting Trends

- San Francisco is 5-1 against the spread (ATS) in its last six games.
- The total has hit the over in five of San Francisco's last seven games.
- Seattle is 15-3 straight up in its last 18 games against San Francisco.
- The total has hit the over in six of Seattle's last nine home games.

49ers vs Seahawks Best Bet

While the Seahawks' defense continues to worsen down the stretch, the 49ers' defense continues to improve. San Francisco has allowed an average of just 8.0 points (No. 1 in NFL) on 296.7 yards (No. 6 in NFL) over its last three games. It has also posted the second-best total DVOA rating in the NFL.

Shanahan's squad is an impressive 7-3 against the spread (ATS) in its last 10 away games and 5-1 ATS in its last six games overall. On the other side, head coach Pete Carroll's team is only 1-4 ATS in its last five games and 4-8 ATS in its last 12 games in December. Trust the 49ers to get the job done.

Bet: San Francisco 49ers -3.5 (-106)

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Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.

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