49ers vs Raiders Prediction, Odds & Best Bets for Week 17 (San Francisco Cruises to Ninth Straight Victory)

Larry Rupp
San Francisco 49ers vs Las Vegas Raiders prediction, odds and best bets for NFL Week 17 game.
San Francisco 49ers vs Las Vegas Raiders prediction, odds and best bets for NFL Week 17 game. / AP Photos/Jed Jacobsohn

49ers vs Raiders Week 17 Game Info

2022 NFL Regular Season — Week 17
San Francisco 49ers (11-4, 4-3 Away) vs. Las Vegas Raiders (6-9, 4-2 Home)
Date: Sunday, Jan. 1, 2023
Time: 4:05 p.m. ET
Venue: Allegiant Stadium — Las Vegas, NV
Coverage: FOX

The San Francisco 49ers will look to keep rising in the NFC standings when they travel to take on the Las Vegas Raiders in Week 17. The 49ers are coming off of a stellar 37-20 win over the Washington Commanders on Sunday. Tight end George Kittle logged 120 yards and 2 touchdowns on 6 catches.

Meanwhile, the Raiders fell short in a 13-10 loss to the Pittsburgh Steelers in Week 16 after they gave up a touchdown with under 2 minutes to go. Quarterback Derek Carr had one of his worst outings of the year, tallying 174 yards, 1 touchdown and 3 interceptions on a 53.3% completion rate (16-of-30).

49ers vs Raiders Odds & Spread

All NFL betting lines, odds and prop bets are from FanDuel Sportsbook.
Moneyline: SF: (-260) | LV: (+215)
Spread: SF: -6 (-110) | LV: +6 (-110)
Total: 44.5 — Over: (-110) | Under: (-110)

The 49ers enter this contest as clear road favorites on the moneyline and spread on FanDuel Sportsbook's odds. This 4:05 p.m. ET clash also features one of the higher totals on the Week 17 slate at 44.5 points.

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49ers vs Raiders Prediction & Pick

The 49ers know that every win down the stretch is important as they attempt to lock down the No. 2 or No. 3 seed in the NFC. The good news is that they run into a Raiders team that has little left to fight for at this point. Another devastating loss in Week 16 eliminated Las Vegas from playoff contention.

San Francisco thrives when it comes to shutting opposing offenses down. It has posted the best total DVOA rating in the NFL and ranks first in opponent points per game (15.3) as well as first in opponent yards per game (290.3). Asking any team, especially the Raiders, to beat that is going to be difficult.

San Francisco is riding an eight-game winning streak and I expect that mark to reach nine on Sunday.

Final Score Prediction: 49ers: 28 | Raiders: 20

49ers vs Raiders Betting Trends

- San Francisco is 6-0 gainst the spread (ATS) in its last six games.
- The total has hit the over in six of San Francisco's last nine games.
- Las Vegas is 1-4 straight up in its last five games against San Francisco.
- The total has hit the under in six of Las Vegas' last nine games.

49ers vs Raiders Best Bet

Seeing this spread listed at less than a touchdown seems surprising. The 49ers are 6-0 against the spread (ATS) in their last six games and have earned an outright win of more than 6 points in each of those contests. San Francisco is also a ridiculous 10-0 ATS in its last 10 games played in January.

The 49ers play their best football at the end of the season, while the Raiders do not. Las Vegas is 2-4 ATS in its last six games played in January and 1-4 ATS in its last five head-to-head matchups against San Francisco, too. Carr is not going to be able to figure out this defense in time to stay competitive.

Bet: San Francisco -6 (-110)

Larry Rupp is not a FanDuel employee. In addition to providing DFS gameplay advice, Larry Rupp also participates in DFS contests on FanDuel using his personal account, username phillyfan424. While the strategies and player selections recommended in his articles are his personal views, he may deploy different strategies and player selections when entering contests with his personal account. The views expressed in their articles are the author's alone and do not necessarily reflect the views of FanDuel. 

Game odds refresh periodically and are subject to change.